Ketorolac/Phenylephrine

DEA Class; Rx

Common Brand Names; Omidria

 Cycloplegics/Mydriatics; Ophthalmic NSAIDs

Combination of an alpha 1-adrenergic receptor agonist (phenylephrine) and a non-selective cyclooxygenase inhibitor (ketorolac)
Used during cataract surgery or intraocular lens replacement and is indicated for maintaining pupil size by preventing intraoperative miosis and reducing post-operative pain
Solution must be diluted in ophthalmic irrigation solution and used during surgery

For intraoperative miosis inhibition and reduction of postoperative ocular pain during cataract surgery or intraocular lens replacement.

Hypersensitivity

>10%

Anterior chamber inflammation (24%)

1-10%

Increased intraocular pressure (4%)

Posterior capsule opacification (4%)

Eye irritation (2%)

Foreign body sensation in eyes (2%)

Systemic exposure of phenylephrine can cause elevations in blood pressure

Potential for cross-sensitivity to acetylsalicylic acid, phenylacetic acid derivatives, and other NSAIDs

Pregnancy

No available data on ketorolac/phenylephrine ophthalmic use in pregnant women or animals to inform any drug associated risks

No well-controlled animal reproduction studies have been conducted with ketorolac/phenylephrine or phenylephrine

Lactation

Data are not available on the presence of ketorolac/phenylephrine in human milk, the effects on the breastfed infant, or the effects on milk production

Systemic exposure to ketorolac/phenylephrine ophthalmic, following a lens replacement procedure is low

4 mL of phenylephrine (1%); ketorolac (0.3%) solution diluted in 500 mL of ophthalmic irrigation solution. Solution is used as needed during surgery.

4 mL of phenylephrine (1%); ketorolac (0.3%) solution diluted in 500 mL of ophthalmic irrigation solution. Solution is used as needed during surgery.

4 mL of phenylephrine (1%); ketorolac (0.3%) solution diluted in 500 mL of ophthalmic irrigation solution. Solution is used as needed during surgery.

4 mL of phenylephrine (1%); ketorolac (0.3%) solution diluted in 500 mL of ophthalmic irrigation solution. Solution is used as needed during surgery.

4 mL of phenylephrine (1%); ketorolac (0.3%) solution diluted in 500 mL of ophthalmic irrigation solution. Solution is used as needed during surgery.

4 mL of phenylephrine (1%); ketorolac (0.3%) solution diluted in 500 mL of ophthalmic irrigation solution. Solution is used as needed during surgery.

ketorolac/phenylephrine

Sterile opthalmic solution concentrate

• 0.3%/1%