This KAPS Quiz contains older questions to help you practise. These questions are no longer used, but they’ll help you understand:
- the types of content covered in each paper of the exam
- how questions might be presented
If you want to practise the sample papers under exam conditions, you’ll need to answer all 100 questions in each paper in 2 hours.
Paper 1 | Pharmaceutical chemistry 50% Pharmacology and physiology 50% |
Paper 2 | Pharmaceutics 50% Therapeutics 50% |
Here is the Test 1 Paper 2
Section 1 = 30 Questions
Section 2 = 70 Questions
Section 1
Small changes in dose may lead to disproportionate increases in blood levels of
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If a fixed dose of a drug that is eliminated by first order kinetics is administered intravenously at regular intervals, the time required to achieve a steady state plasma level depends only on the
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A basic principle of drug absorption is that a drug is usually NOT absorbed
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The system which is composed of a liquid dispersed in a liquid is
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Which of the following characteristics is CORRECT for cationic aqueous creams?
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Which of the following drugs is NOT absorbed systemically when given by mouth?
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Occlusive dressings are used clinically with topical corticosteroids to
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If a drug has a very small volume of distribution (Vd), it is likely that this drug
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The route of drug administration that will give the MOST rapid onset of the pharmacologic effect is
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The bioequivalence of two tablets containing an identical amount of the same drug manufactured by different companies is best determined by measuring
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Thiopentone is of shorter duration of action than phenobarbitone because thiopentone
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Which of the following is NOT administered as a racemic mixture?
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Drugs that demonstrate non-linear pharmacokinetics show which of the following properties?
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It was determined that 95% of an oral 80-mg dose of verapamil was absorbed in a 70 kg test subject. However, because of extensive biotransformation during its first pass through the portal circulation, the bioavailability of verapamil was only 25%. Assuming a liver blood flow of 1500 mL/min, the hepatic clearance of verapamil in this situation was:
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A new cardiac glycoside has been developed for oral and intravenous (IV) administration. The drug has an elimination half-life of 24 hours and an apparent volume of distribution (Vd) of 3 L/kg.The effective drug concentration in plasma is 1.5 ng/mL. Toxic effects of the drug are observed at drug concentrations above 4 ng/mL. The drug is 75% bioavailable after an oral dose.Calculate an oral maintenance dose to be given once a day for a 65 kg male patient (age 68 years) with congestive heart failure and normal renal function. The aim is to achieve an average plasma concentration of 1.5 ng/mL. The dose should be
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Salicylic acid has a pKa of 3.0 and undergoes significant renal tubular reabsorption. In aspirin overdose the renal clearance of salicylic acid will be increased to the greatest extent by
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Which of the following drugs has the longest half-life?
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The most common bacterial genus associated with acne vulgaris is
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Which of the following microbes will NOT be covered by clindamycin?
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The five antibody classes are
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Which of the following statements is FALSE in regards to the use of combination antiinfective therapy?
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Which of the following regimens is appropriate for managing herpes simplex encephalitis?
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All of the following are official pharmacopoeial testing procedures for tablets EXCEPT
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An example of an osmotic laxative is
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A suspension is NOT a suitable dosage form for what type of injection?
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Insulin preparations are usually administered by
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Methylcellulose and similar agents are MOST commonly used in ophthalmic solutions to
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In which base should hydrocortisone acetate be incorporated to give maximal topical absorption?
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The term "impalpable" refers to a substance that is
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Sodium metabisulphite is used as
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The KAPS (Knowledge Assessment of Pharmaceutical Sciences) Exam Tests 1 Paper 2 Section 1
Result
Paper 2 Section 1 Pharmaceutics Passing Score 50%FAIL
Result
Paper 2 Section 1 Pharmaceutics Passing Score 50%Pass
Section 2
Data obtained from two different batches of tablets of a new hypoglycaemic agent undergoing clinical trial revealed that Batch 1 contains 200 mg of the drug and has an absolute bioavailability of 55%.Batch 2 contains 200 mg of the drug and relative to the first batch has a bioavailability of 165%What is the absolute bioavailability of the second batch?
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How much ichthammol would be required to be added to a 5% w/w ichthammol in yellow soft paraffin ointment to prepare 200 g of a 17.5% w/w ichthammol in yellow soft paraffin ointment?
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How many grams of chlorbutol are required to make 500 mL of an aqueous solution of such a concentration that 25 mL diluted to 100 mL with water will give a 1:2000 solution?
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Dopamine 200 mg in 500 mL of normal saline at 5 μg/kg/min is ordered for a 70 kg patient. At what rate (mL/min) should the solution be infused to deliver the desired dose of 5 μg/kg/min?
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Lignocaine hydrochloride is available for intravenous injection as a 2% solution packed in 5 mL disposable syringes. The dose is 1 mg per kg of body weight by slow intravenous injection.The volume of solution that should be used for a patient weighing 60 kg is
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A solution with a concentration of 0.0125 % may also be described as containing
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Lugol's Solution contains 5% of iodine, and the usual dose of the solution is 0.3 mL three times a day. The amount of iodine contained in the daily dose of the solution is
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An infusion solution of sodium chloride 0.9% contains a sodium ion concentration of
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A pharmacist has to prepare an aqueous solution containing 1 g of benzalkonium chloride in 2 L, by diluting a 10% solution. How many mL of water will be required?
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The normal daily adult oral dose of celecoxib is within the range
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Which of the following β-adrenergic blockers is predominantly renally cleared?
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Dose levels of vancomycin should be reduced in patients suffering from
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The normal adult daily dose of hydrochlorothiazide is within the range
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For ongoing control of seizures phenytoin may be administered
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Which of the following drugs should NOT be added to the therapy of a poorly controlled diabetic patient already on maximum doses of metformin and glibenclamide?
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Which of the following medicines is NOT safe to use in children under 12 years of age?
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Naloxone
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Sodium Chloride 0.9% is a good wound cleansing agent for the following reasons EXCEPT it
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Which one of the following statements relating to carbamazepine is FALSE?
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Mr Earl, a patient with congestive heart failure, has been taking digoxin 125 mcg/day for one month and has a plasma digoxin concentration of 0.5 mcg/L(The therapeutic range for digoxin in patients with congestive heart failure is 0.5-0.8 mcg/L.)Mr Earl is not showing adequate clinical improvement. The MOST appropriate course of action is to
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Mood disorders are being more widely managed with anticonvulsants. Which of the following is FALSE with regard to anticonvulsants used in this fashion?
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When considering the usefulness of metformin monotherapy for a patient with type 2 diabetes mellitus, relevant patient factors to consider include
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When monitoring anticoagulation with heparin, which of the following does NOT apply?
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The Mantoux test uses
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Which of the following is NOT true of methadone?
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Interferons are indicated in which of the following conditions?
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Which of the following compounds is unlikely to contribute to serotonin syndrome?
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A 75-year-old male, with carcinoma of the prostate with local metastatasis, would be best treated with which of the following?
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Metoclopramide is often given together with oral aspirin for the treatment of acutemigraine attacks. The rationale behind the use of metoclopramide is that it will
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Which of the following drugs has been associated with interstitial pulmonary fibrosis?
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Methysergide, when used for the prophylaxis of migraine
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Cationic exchange resins are most commonly used to treat
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Which of the following procedures should be used to monitor effective enoxaparin doses?
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The following drugs can cause syndrome of inappropriate anti diuretic hormone (SIADH) EXCEPT
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Chronic phenytoin therapy has been associated with
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Which of the following properties is NOT true of indomethacin?
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Which one of the following antipsychotic agents provides the lowest risk of extrapyramidal side effects?
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Which of the following is contraindicated in nursing mothers because it inhibits milk production?
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A 47-year-old premenopausal female with endometriosis is treated with danazol. Which of the following adverse effects is associated with danazol?
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The most prevalent side effect of the chronic use of aluminium hydroxide gel is
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Which of the following is a common sign of digoxin toxicity?
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Sensitisation to sunlight may be produced in a patient being treated with
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A common anticholinergic (atropine-like) side-effect of many drugs is
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The use of pethidine in the management of chronic pain is discouraged because it
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Halothane
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Which of the following has been shown to be teratogenic?
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Moclobemide is useful in Parkinson's disease because it inhibits
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Which of the following has been shown to cause syndrome of inappropriate antidiuretic hormone release (SIADH)?
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Which of the following is associated with lethargy, nightmares and cold extremities as side effects?
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The following medicines have been reported to cause asthma attacks in susceptible people EXCEPT
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Amiodarone may cause all of the following EXCEPT
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The following drugs can cause an increase in the plasma concentration of digoxin with increased risk of toxicity EXCEPT
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Food containing tyramine should NOT be part of the diet of patients taking which of the following antidepressants?
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Theophylline has a very narrow therapeutic index. This drug has severe dose related toxicity (seizures and arrhythmias) which may occur without preceding milder symptoms of toxicity (vomiting and diarrhoea).Theophylline concentrations are raised by a number of commonly used drugs. Three such drugs are
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Which of the following compounds may increase the effects of warfarin?
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Which or the following oral antibiotics should not be taken at the same time as oral iron (Fe2+) containing products?
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If a patient stabilised on digoxin is then administered amiodarone
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The following points should be included in your counselling advice to a person using topical sunscreen agents to prevent sunburn EXCEPT
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The preferred thyroid preparation for maintenance replacement therapy is which of the following drugs?
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Single daily doses of simvastatin are best taken at
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When dispensing a prescription for sucralfate the pharmacist should tell the patient that
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Which of the following anticonvulsants is included in pregnancy Category D?
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A patient with a superficial wound asks what time period is recommended between tetanus immunisations?
Please select 2 correct answers
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Time to peak effect of salmeterol is
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In Parkinson's disease which of the following drugs is contraindicated?
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Which of the following adverse effects could be seen with hydrochlorothiazide?
1
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Each Slow-K dosage unit contains 8 mmoL of potassium as potassium chloride. How many mg of potassium chloride are in each Slow-K tablet? [Atomic Weight K = 39, Cl = 35]
1
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Which of the following agents is MOST similar to hydrochlorothiazide?
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When captopril is added to Ms Williams’ regimen, there is an increased likelihood of
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Captopril is MOST similar in action to
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The KAPS (Knowledge Assessment of Pharmaceutical Sciences) Exam Tests 1 Paper 2 Section 2
Result
Paper 2 Section 1 Pharmaceutics Passing Score 50%FAIL
Result
Paper 2 Section 1 Pharmaceutics Passing Score 50%Pass