Indapamide

DEA Class; Rx

Common Brand Names; Lozol

• Diuretics, Other

Codeine is an opiate agonist antitussive agent; guaifenesin is an expectorant
Used in combination to treat cough
Not indicated in pediatric patients under 18 years of age; contraindicated for cough and cold in neonates, infants and children less than 12 years of age; contraindicated in adolescent pediatric patients 12 to 18 years after tonsillectomy or adenoidectomy

Indicated for the treatment of heart failure.

Hypersensitivity to indapamide or sulfonamides

Anuria

• Hypotension
• Palpation
• Flushing
• Dizziness
• Lightheadedness
• Vertigo
• Headache
• Weakness
• Restlessness
• Drowsiness
• Fatigue
• Lethargy
• Malaise
• Anorexia
• Nausea/vomiting
• Nocturia
• Polyuria
• Blurred vision
• Rhinnorhea
• Electrolyte abnormalities
• Pruritus
• Rash
• Cutaneous vasculitis
• Glycosuria
• Pancreatitis

Serum concentrations of uric acid increased by an average of 0.69 mg/100 mL in patients treated with indapamide 1.25 mg, and by an average of 1.0 mg/100 mL in patients treated with indapamide 2.5 mg and 5.0 mg, and frank gout may be precipitated in certain patients receiving indapamide; periodically monitor serum concentrations of uric acid during treatment

Use with caution in patients with severe renal disease, as reduced plasma volume may exacerbate or precipitate azotemia; if progressive renal impairment observed consider withholding or discontinuing diuretic therapy; renal function tests should be performed periodically during treatment

Use with caution in patients with impaired hepatic function or progressive liver disease; minor alterations of fluid and electrolyte balance may precipitate hepatic coma

Latent diabetes may become manifest and insulin requirements in diabetic patients may be altered during thiazide administration; serum concentrations of glucose should be monitored routinely during treatment

Calcium excretion is decreased by diuretics pharmacologically related to indapamide; prolonged treatment with drugs pharmacologically related to indapamide may be rarely associated with hypercalcemia and hypophosphatemia secondary to physiologic changes in parathyroid gland; treatment should be discontinued before tests for parathyroid function are performed

Therapy may decrease serum protein-bound iodine levels without signs of thyroid disturbance

Thiazides have exacerbated or activated systemic lupus erythematosus; consider possibility with this therapy as well

Pregnancy Category: B

Lactation: not known if excreted into breast milk, avoid