General Description
Synonyms:E1440; hydroxylpropyl starch.
Description:Hydroxypropyl starch occurs as a free-flowing white to off-white coarse powder
Chemical Name: Hydroxypropyl starch
Functions
Binding agent; disintegrant; emulsifying agent; thickening agent; viscosity-increasing agent.
Uses
Hydroxypropyl starch is a modified starch and has been used in combination with carrageenan in the production of soft capsules.
Hydroxypropyl starch has been used experimentally in hydrophilic matrices, where it was shown to be an effective matrix for tablets designed for controlled-release drug delivery systems.
It has also been used experimentally in the production of hydrophilic matrices by direct compression.
It is used in antiseptics and is used widely in cosmetics.
It is also used analytically as a bioseparation aqueous-phase-forming polymer.
Incompatibilities
Hydroxypropyl starch–methyl methacrylate (HS-MMA) has been used experimentally in hydrophilic matrices produced by direct compression. Pregelatinized hydroxypropyl starch has been shown to exhibit good disintegrating properties, and can be used as a binder in wet granulation
Safety
Hydroxypropyl starch is widely used in cosmetics and food products. It is also used in oral pharmaceutical formulations. The WHO has set an acceptable daily intake for hydroxypropyl starch at ‘not limited’ since it was well tolerated on oral consumption
Handling Precautions
Observe normal precautions appropriate to the circumstances and quantity of material handled.