Skip to content

Hydroxypropyl Betadex

    Synonyms: Cavasol W7; 2-hydroxypropyl-b-cyclodextrin; 2-hydroxypropyl cyclomaltoheptaose; hidroksipropilbetadeksas; hydoxipropylbetadex; hydroksipropylbetadeksi; hydroxypropylbetadeksum; hydroxypropylbetadexum; Kleptose HPB.

    Description:  Hydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.

    Chemical Name: b-Cyclodextrin, 2-hydroxypropyl ether

    Complexing agent; dissolution enhancer; release-modifying agent; sequestering agent; solubilizing agent; stabilizing agent; tonicity agent.

    • Hydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids, oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations.

    • It has also been shown to act as a stabilizer during processing and storage of formulations.

    • Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials.

    • The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility.

    The pharmaceutical toxicology of hydroxypropyl betadex has been reviewed, and in general, the material was found to be of low toxicity. It has been suggested that hydroxypropyl betadex may have a synergistic toxic effect with, for example, carcinogens, by increasing their solubility and thus bioavailability

    Observe normal precautions appropriate to the circumstances and quantity of the material handled.

    Cyclodextrins; 3-hydroxypropyl-b-cyclodextrin; sulfobutylether bcyclodextrin