Hydroxypropyl Betadex

Synonyms: Cavasol W7; 2-hydroxypropyl-b-cyclodextrin; 2-hydroxypropyl cyclomaltoheptaose; hidroksipropilbetadeksas; hydoxipropylbetadex; hydroksipropylbetadeksi; hydroxypropylbetadeksum; hydroxypropylbetadexum; Kleptose HPB.

Description:  Hydroxypropyl betadex occurs as a white or almost white, amorphous or crystalline powder.

Chemical Name: b-Cyclodextrin, 2-hydroxypropyl ether

Complexing agent; dissolution enhancer; release-modifying agent; sequestering agent; solubilizing agent; stabilizing agent; tonicity agent.

• Hydroxypropyl betadex has been widely investigated in pharmaceutics and has principally been used as a solubilizer for hydrophobic molecules in oral liquids, oral solids, parenterals, pressurized metered dose inhalers, dry powder inhalers, and topical formulations.

• It has also been shown to act as a stabilizer during processing and storage of formulations.

• Hydroxypropyl betadex inclusion complexes have been reported to show mechanical properties distinct from the pure materials.

• The reported advantage of hydroxypropyl betadex over unsubstituted b-cyclodextrin is its greater water solubility.

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The pharmaceutical toxicology of hydroxypropyl betadex has been reviewed, and in general, the material was found to be of low toxicity. It has been suggested that hydroxypropyl betadex may have a synergistic toxic effect with, for example, carcinogens, by increasing their solubility and thus bioavailability

Observe normal precautions appropriate to the circumstances and quantity of the material handled.

Cyclodextrins; 3-hydroxypropyl-b-cyclodextrin; sulfobutylether bcyclodextrin