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Hydrocortisone/Neomycin/Polymyxin Otic

    Brands

    DEA Class; Rx

    Common Brand Names; Cortisporin Otic

    • Antibiotics/Corticosteroids, Otic

    Corticosteroid anti-inflammatory and antibiotic combination
    Treats primarily gram-negative, aerobic bacteria, but are also effective against Staphylococcus aureus
    Available in ophthalmic, otic, and topical forms

    Indicated for the treatment of superficial bacterial infections of the external auditory canal (i.e., otitis externa) caused by susceptible organisms, and for the treatment of infections of mastoidectomy and fenestration caused by susceptible organisms.

    For the treatment of corticosteroid-responsive inflammatory ocular conditions and where bacterial ophthalmic infection or a risk of bacterial ophthalmic infection exists (e.g., inflammation of palpebral and bulbar conjunctiva, cornea and anterior segment of the globe where the inherent risk of corticosteroid use in bacterial conjunctivitis is accepted to obtain a decrease in edema and inflammation; also in chronic anterior uveitis and corneal injury from chemical, radiation, or thermal burns, or penetration of foreign objects).
    For the treatment of corticosteroid-responsive dermatoses with secondary infection.

    Hypersensitivity to any agent

    Cutaneous viral infection of the external auditory canal (solution only); patients with herpes simplex, vaccinia, and varicella infections

    Hypersensitivity

    Itching

    Redness

    Skin rash

    Swelling

    Neomycin sensitization, including itching, reddening, edema, and failure to heal may occur; discontinue therapy if it occurs

    Solution does not penetrate quite as well as suspension does

    Systemic absorption of topical corticosteroids may cause hypothalamic-pituitary-adrenal axis suppression, which may lead to adrenal crisis, especially in children and in patients receiving large doses for prolonged periods

    Prolonged use of corticosteroids may increase the incidence of secondary infection, mask acute infection, and may also prolong or exacerbate viral infections

    Development of Kaposi sarcoma associated with prolonged treatment with corticosteroids; discontinue therapy if it occurs

    Neomycin can induce permanent sensorineural hearing loss due to cochlear damage, including destruction of hair cells in the organ of Corti; risk of ototoxicity is greater with prolonged use

    Percutaneous absorption of topical corticosteroids may occur, which may cause manifestations of hyperglycemia, Cushing syndrome, or glycosuria; use of occlusive dressings, application fo denuded skin, or application to large surface areas may increase risk of absorption

    Pregnancy category: C

    Lactation: Unknown whether drug is excreted in milk; use with caution

    Adults

    Maximum dosage information not available.

    Geriatric

    Maximum dosage information not available.

    Adolescents

    Maximum dosage information not available.

    Children

    Maximum dosage information for otic product not available; safety and efficacy of ophthalmic and topical products not established.

    Infants

    Maximum dosage information for otic product not available; safety and efficacy of ophthalmic and topical products not established.

    Hydrocortisone/neomycin/polymyxin otic

    otic solution/suspension

    • 10mg (1%)/3.5mg (0.35%)/10000units/10mL