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Guaifenesin / Oxtriphylline (Choline Theophyllinate)

    DAE Class; Rx


    • Bronchodilator-Expectorant

    Oxtriphylline and guaifenesin combination is used to treat or prevent the symptoms of asthma or to treat chronic bronchitis and emphysema. This medicine relieves cough, wheezing, shortness of breath, and troubled breathing. It works by opening up the bronchial tubes (air passages of the lungs) and increasing the flow of air through them.

    Oxtriphylline / Guaifenesin is contraindicated in those patients
    who have shown hypersensitivity to it or to other theophylline derivatives; in coronary artery disease when in the physician’s judgment myocardial stimulation might prove harmful, in individuals with underlying seizure disorders (unless receiving appropriate anticonvulsant medication). It should not be used in patients with peptic ulcer.

    Less common or rare

    • Heartburn and/or vomiting

    Symptoms of toxicity

    • Abdominal pain, continuing or severe
    • confusion or change in behavior
    • convulsions (seizures)
    • dark or bloody vomit
    • diarrhea
    • dizziness or lightheadedness
    • fast and/or irregular heartbeat, continuing
    • nervousness or restlessness, continuing
    • trembling, continuing

    Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    Less common

    • Headache
    • fast heartbeat
    • increased urination
    • nausea
    • nervousness
    • trembling
    • trouble in sleeping

    Your doctor should check your progress at regular visits, especially for the first few weeks after you begin using this medicine. A blood test may be taken to help your doctor decide whether the dose of this medicine should be changed.

    The oxtriphylline in this medicine may add to the central nervous system stimulant effects of caffeine-containing foods or beverages such as chocolate, cocoa, tea, coffee, and cola drinks. Avoid eating or drinking large amounts of these foods or beverages while taking this medicine . If you have any questions about this, check with your doctor.

    A change in your usual behavior or physical well-being may affect the way this medicine works in your body. Check with your doctor if you:

    • have a fever of 102 °F or higher for at least 24 hours or higher than 100 °F for longer than 24 hours.
    • start or stop smoking.
    • start or stop taking another medicine.
    • change your diet for a long time.

    Before you have myocardial perfusion studies (a medical test that shows how well blood is flowing to your heart), tell the medical doctor in charge that you are taking this medicine. The results of the test may be affected by this medicine.


    CHOLEDYL EXPECTORANT crosses the placental barrier and also passes freely into breast milk, where concentrations are similar to plasma levels. Safe use in pregnancy has not been established relative to possible adverse effects on fetal development, but neither have adverse effects on fetal development been established. Therefore, the use of theophylline in pregnant women should be balanced against the risk of uncontrolled asthma.

    Breast Feeding

    There are insufficient adequate and well-controlled studies in lactating women. Therefore, CHOLEDYL EXPECTORANT should be used in nursing mothers only if clearly needed.

    Guaifenesin / Oxtriphylline (Choline Theophyllinate)


    • 60 ml
    • 120 ml
    • 250 ml