General Description
Synonyms: Glycofurol 75; tetraglycol; a-(tetrahydrofuranyl)-o-hydroxy-poly(- oxyethylene); tetrahydrofurfuryl alcohol polyethylene glycol ether; THFP.
Note: tetraglycol is also used as a synonym for tetrahydrofurfuryl alcohol
Description: Glycofurol is a clear, colorless, almost odorless liquid, with a bitter taste; it produces a warm sensation on the tongue.
Chemical Name: a-[(Tetrahydro-2-furanyl)methyl]-o-hydroxy-poly(oxy-1,2-ethanediyl)
Uses
Glycofurol is used as a solvent in parenteral products for intravenous or intramuscular injection in concentrations up to 50% v/v.
It has also been investigated, mainly in animal studies, for use as a penetration enhancer and solvent in topical and intranasal formulations.
Glycofurol has also been used at 20% v/v concentration in a rectal formulation.
Incompatibilities
Incompatible with oxidizing agents.
Safety
Glycofurol is mainly used as a solvent in parenteral pharmaceutical formulations and is generally regarded as a relatively nontoxic and nonirritant material at the levels used as a pharmaceutical excipient. Glycofurol can be irritant when used undiluted; its tolerability is approximately the same as propylene glycol.
Handling Precautions
Observe normal precautions appropriate to the circumstances and quantity of material handled.