Glycine

Synonyms: Aminoacetic acid; 2-aminoacetic acid; E640; G; Gly; glycinum; glycoamin; glycocoll; glycoll; glycolixir; glycinium; Hampshire glycine; padil; sucre de ge´latine.

Description:  Glycine occurs as a white, odorless, crystalline powder, and has a sweet taste.

Chemical Name: Aminoethanoic acid

Buffering agent; bulking agent; dietary supplement; freeze-drying agent; tablet disintegrant; wetting agent.

• Glycine is routinely used as a cofreeze-dried excipient in protein formulations owing to its ability to form a strong, porous, and elegant cake structure in the final lyophilized product.

• It is one of the most frequently utilized excipients in freeze-dried injectable formulations owing to its advantageous freeze-drying properties.

• Glycine has been investigated as a disintegration accelerant in fast-disintegrating formulations owing to its excellent wetting nature.

• It is also used as a buffering agent and conditioner in cosmetics.

• Glycine may be used along with antacids in the treatment of gastric hyperacidity, and it may also be included in aspirin preparations to aid the reduction of gastric irritation

Glycine may undergo Maillard reactions with amino acids to produce yellowing or browning. Reducing sugars will also interact with secondary amines to form an imine, but without any accompanying yellow-brown discoloration.

Glycine is used as a sweetener, buffering agent, and dietary supplement. The pure form of glycine is moderately toxic by the IV route and mildly toxic by ingestion.

Observe normal precautions appropriate to the circumstances and quantity of the material handled. When heated to decomposition, glycine emits toxic fumes of nitrogen oxides.

Glycine hydrochloride; sodium glycinate.