Glyceryl Palmitostearate

Synonyms: Glycerin palmitostearate; glycerol palmitostearate; 2-[(1-oxohexadecyl)-oxy]-1,3-propanediyl dioctadecanoate and 1,2,3-propane triol; Precirol ATO 5.

Description:Glyceryl palmitostearate occurs as a fine white powder with a faint odor.

Chemical Name: Octadecanoic acid, 2,3-dihydroxypropyl ester mixed with 3- hydroxy-2-[(1-oxohexadecyl)-oxy] propyl octadecanoate

Biodegradable material; coating agent; gelling agent; releasemodifying agent; sustained-release agent; tablet and capsule diluent; tablet and capsule lubricant; taste-masking agent.

• Glyceryl palmitostearate is used in oral solid-dosage pharmaceutical formulations as a lubricant.

• Disintegration times increase and tablet strength decreases with increase in mixing time.

• It is used as a lipophilic matrix for sustained-release tablet and capsule formulations.

• Tablet formulations may be prepared by either granulation or a hot-melt technique, the former producing tablets that have the faster release profile. Release rate decreases with increased glyceryl palmitostearate content.

• Glyceryl palmitostearate is used to form microspheres, which may be used in capsules or compressed to form tablets, pellets, coated beads, and biodegradable gels.

• It is also used for taste-masking

Glyceryl palmitostearate is incompatible with ketoprofen(15) and naproxen

Glyceryl palmitostearate is used in oral pharmaceutical formulations and is generally regarded as an essentially nontoxic and nonirritant material.

Observe normal handling precautions appropriate to the circumstances and quantity of material handled.

Glyceryl behenate; glyceryl monostearate