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Glyceryl Monooleate

    Synonyms: Aldo MO; Atlas G-695; Capmul GMO; glycerol-1-oleate; glyceroli mono-oleas; glyceryl mono-oleate; HallStar GMO; Imwitor 948; Kessco GMO; Ligalub; monolein; Monomuls 90-O18; mono-olein; a-mono-olein glycerol; Peceol; Priolube 1408; Stepan GMO; Tegin.

    Description:The PhEur 6.3 describes glyceryl monooleate as being a mixture of monoacylglycerols, mainly monooleoylglycerol, together with variable quantities of di- and triacylglycerols. They are defined by the nominal content of monoacylglycerols (see Table I) and obtained by partial glycerolysis of vegetable oils mainly containing triacylglycerols of oleic acid or by esterification of glycerol by oleic acid, this fatty acid being of vegetable or animal origin. A suitable antioxidant may be added. Glyceryl monooleates occur as amber oily liquids, which may be partially solidified at room temperature and have a characteristic odor.

    Chemical Name: 9-Octadecenoic acid (Z), monoester with 1,2,3-propanetriol

    Bioadhesive material; emollient; emulsifying agent; emulsion stabilizer; gelling agent; mucoadhesive; nonionic surfactant; sustained-release agent

    • Glyceryl monooleate is a polar lipid that swells in water to give several phases with different rheological properties.

    • It is available in both nonemulsifying (n/e) and self-emulsifying (s/e) grades, the self-emulsifying grade containing about 5% of an anionic surfactant.

    • The nonemulsifying grade is used in topical formulations as an emollient and as an emulsifying agent for water-in-oil emulsions. It is also a stabilizer for oil-in-water emulsions.

    • The self-emulsifying grade is used as a primary emulsifier for oil-in-water systems.

    • Glyceryl monooleate gels in excess water, forming a highly ordered cubic phase that can be used to sustain the release of various water-soluble drugs.

    • It is also the basis of mucoadhesive drug delivery systems.

    • Glyceryl monooleate is reported to enhance transdermal and buccal penetration.

    Glyceryl monooleate is incompatible with strong oxidizing agents. The self-emulsifying grade is incompatible with cationic surfactants.

    Glyceryl monooleate is used in oral and topical pharmaceutical formulations and is generally regarded as a relatively nonirritant and nontoxic excipient.

    Observe normal precautions appropriate to the circumstances and quantity of material handled.

    Glyceryl monostearate.