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Fenoldopam

    Brands

    DEA Class;  Rx

    Common Brand Names; Corlopam

    • Vasodilators; 
    • Endocrine, Dopamine Agonists

    Intravenous dopamine1 agonist
    Used for in-hospital, short-term (up to 48 hours) treatment of severe hypertension
    Transition to oral therapy after blood pressure stable during fenoldopam infusion

    For the short-term treatment of severe hypertension (e.g., hypertensive emergency).
    For nephrotoxicity prophylaxis† in patients undergoing cardiac surgery.

    Hypersensitivity to fenoldopam and sulfite

    • Angina
    • Cardiac dysrhythmia
    • Dizziness
    • Flushing
    • Heart failure
    • Hypotension
    • Myocardial infarction
    • Tachycardia
    • Headache
    • Nausea
    • Vomiting
    • Serum creatinine raised
    • Cardiac disorders: Cardiogenic shock
    • Gastrointestinal disorders: Abdominal distension

    Causes a dose-related tachycardia, particularly with infusion rates above 0.1 mcg/kg/min

    Monitor potassium levels

    Increased intraocular pressure in patients with glaucoma or intraocular hypertension

    Contains sodium metabisulfite, a sulfite that may cause allergic-type reactions including anaphylactic symptoms in susceptible patients

    There are insufficient data regarding use in pregnancy to evaluate for a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes

    There are no data on presence of drug in human milk, effects on breastfed child, or on milk production; drug is present in rat milk; when a drug is present in animal milk, it is likely that the drug will be present in human milk

    Adults

    1.6 mcg/kg/minute IV.

    Geriatric

    1.6 mcg/kg/minute IV.

    Adolescents

    0.8 mcg/kg/minute IV.

    Children

    0.8 mcg/kg/minute IV.

    Infants

    0.8 mcg/kg/minute IV.

    Neonates

    Weighing 2 kg or more: 0.8 mcg/kg/minute IV.

    Fenoldopam mesylate

    injectable solution

    • 10mg/mL