Classes
DAE Class; Rx
Common Brand Names; Emcyt
- Antineoplastics, Hormones
Description
Oral nitrogen mustard antineoplastic agent; linked to an estradiol molecule; used primarily for hormone-refractory prostate CA; used off-label for breast CA and malignant glioma.
Indications
Contraindications
Hypersensitivity to estradiol or nitrogen mustard
Active thrombophlebitis or thromboembolic disorder, except when tumor mass is cause of thromboembolic phenomenon and benefits of therapy outweigh risk
Adverse Effects
>10%
Edema
Dyspnea
Nausea
Diarrhea
Breast tenderness and enlargement
1-10%
Lethargy
Insomnia
Cerebrovascular accident
Myocardial infarction
Thrombophlebitis
Pulmonary embolism
Congestive heart failure
Easy bruising
Anorexia
Vomiting
Pruritus
Dry skin
Impotence
Leg cramps
Leukopenia
Decreased testosterone
Abnormality of hepatic enzymes and/or bilirubin
Warnings
Increased risk of thrombosis, including fatal and non-fatal MI
Liver dysfunction, metabolic bone disease associated with hypercalcemia, renal insufficiency
History of thromoboembolic phenomenon especially associated with estrogen therapy
Decreased glucose tolerance-monitor diabetics
Risk of HTN-monitor BP periodically
May cause fluid retention with exacerbation of CHF, peripheral edema, or conditions influenced by fluid retention, such as epilepsy, migraine, renal dysfunction
May cause gynecomastia and impotence
Allergic reactions, including angioedema of airway has been reported
Avoid becoming pregnant
Pregnancy and Lactation
Pregnancy Category: X
Lactation: not intended for use in women
Maximum Dosage
Adults
16 mg/kg per day.
Geriatric
16 mg/kg per day.
Adolescents
Safety and efficacy have not been established.
Children
Safety and efficacy have not been established.
How supplied
Estramustine
capsule
- 140mg