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Erythromycin / Sulfisoxazole

    Brands

    DEA Class;  Rx

    Common Brand Names; Pediazole

    • Sulfonamides

    Erythromycin: Erythromycin: Macrolide antibiotic; iInhibits bacterial growth, possibly by blocking dissociation of peptidyl tRNA from ribosomes, causing RNA-dependent protein synthesis to arrest

    Sulfisoxazole: Sulfonamide derivative; exerts bacteriostatic action by antagonizing para-aminobenzoic acid (PABA), an essential component in folic acid synthesis

    Not prescribed for adults

    FOR PEDIATRIC

    • H. influenzae Acute Otitis Media

    Hypersensitivity to macrolides, sulfonamides, sulfonylureas, thiazides

    Term pregnancy

    Lactation

    Age <2 months

    Porphyria

    G-6-PD deficiency

    Severe hepatic or renal impairment (CrCl <15 mL/min), documented megaloblastic or folate deficiency anemia, obstructive uropathy

    • Abdominal pain and discomfort
    • Diarrhea
    • Lack or loss of appetite
    • Nausea
    • Vomiting
    • Anxiety
    • Arrythmia
    • Blood disorders
    • Blood or stone formation in urine
    • Bluish discoloration of skin
    • Chills
    • Colitis
    • Convulsions
    • Cough
    • Melena
    • Depression
    • Dermatitis
    • Difficulty/inability to urinate
    • Disorientation
    • Dizziness
    • Drowsiness
    • Dystonia
    • Exhaustion
    • Fainting
    • Fatigue
    • Fluid retention
    • Flushing
    • Fever
    • Gas
    • GI bleeding
    • Hallucinations
    • Headache
    • Hepatitis
    • Hives
    • Hypoglycemia
    • Insomnia
    • Itching
    • Polyuria
    • Stoamtitis
    • Redness & swelling of tongue
    • Tinnitus
    • Sensitivity to light
    • Severe allergic reactions
    • Severe skin welts or swelling
    • Shortness of breath
    • Skin rash
    • Stevens-Johnson syndrome
    • Swelling around the eye
    • Temporary hearing loss
    • Vertigo
    • Weakness

    –

    Pregnancy Category: C

    Lactation: enters breast milk

    H. influenzae Acute Otitis Media

    <2 months: Contraindicated

    >2 months: 50 mg/kg/day (erythromycin) or 150 mg/kg/day (sulfisoxazole) PO divided q6-8hr for 10 days  

    Not to exceed 6 g/day sulfisoxazole

    Erythromycin base / Sulfisoxazole

    Oral suspension

    • (200mg/600mg)/5mL