Classes
DEA Class; Rx
Common Brand Names; Pediazole
- Sulfonamides
Description
Erythromycin: Erythromycin: Macrolide antibiotic; iInhibits bacterial growth, possibly by blocking dissociation of peptidyl tRNA from ribosomes, causing RNA-dependent protein synthesis to arrest
Sulfisoxazole: Sulfonamide derivative; exerts bacteriostatic action by antagonizing para-aminobenzoic acid (PABA), an essential component in folic acid synthesis
Indications
Not prescribed for adults
FOR PEDIATRIC
- H. influenzae Acute Otitis Media
Contraindications
Hypersensitivity to macrolides, sulfonamides, sulfonylureas, thiazides
Term pregnancy
Lactation
Age <2 months
Porphyria
G-6-PD deficiency
Severe hepatic or renal impairment (CrCl <15 mL/min), documented megaloblastic or folate deficiency anemia, obstructive uropathy
Adverse Effects
- Abdominal pain and discomfort
- Diarrhea
- Lack or loss of appetite
- Nausea
- Vomiting
- Anxiety
- Arrythmia
- Blood disorders
- Blood or stone formation in urine
- Bluish discoloration of skin
- Chills
- Colitis
- Convulsions
- Cough
- Melena
- Depression
- Dermatitis
- Difficulty/inability to urinate
- Disorientation
- Dizziness
- Drowsiness
- Dystonia
- Exhaustion
- Fainting
- Fatigue
- Fluid retention
- Flushing
- Fever
- Gas
- GI bleeding
- Hallucinations
- Headache
- Hepatitis
- Hives
- Hypoglycemia
- Insomnia
- Itching
- Polyuria
- Stoamtitis
- Redness & swelling of tongue
- Tinnitus
- Sensitivity to light
- Severe allergic reactions
- Severe skin welts or swelling
- Shortness of breath
- Skin rash
- Stevens-Johnson syndrome
- Swelling around the eye
- Temporary hearing loss
- Vertigo
- Weakness
Pregnancy and Lactation
Pregnancy Category: C
Lactation: enters breast milk
How supplied
Erythromycin base / Sulfisoxazole
Oral suspension
- (200mg/600mg)/5mL