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Terconazole

    DEA Class; Rx

    Common Brand Names; Terazol, Terazol 3, Terazol 7

    • Antifungals, Vaginal

    Intravaginal azole antifungal
    Used for vaginal candidiasis; usually fungicidal against Candida albicans

    Indicated for Candidal Vulvovaginitis

    Hypersensitivity

    • Headache
    • Abdominal pain
    • Chills
    • Fever
    • Dysmenorrhea
    • Vulvar/vaginal burning
    • Dysmenorrhea
    • Vulvar itching, soreness, edema, or discharge
    • Polyuria
    • Burning or itching of penis of sexual partner
    • Flu-like syndrome

    Discontinue if irritation or sensitization occurs

    Perform/repeat microbiological studies (KOH smear and/or cultures) in patients not responding to terconazole to rule out other pathogens

    Anaphylaxis and toxic epidermal necrolysis (TENs) reported; discontinued if anaphylaxis or TENs develops

    Product is petroleum-based, which may damage latex or rubber condoms or diaphragms (separate use by 3 days)

    Discontinue use if toxic epidermal necrolysis occurs; institute supportive therapy and monitoring; do not reinstitute therapy

    If flu-like symptoms or chills, fever occur, discontinue therapy and do not reinitiate

    Pregnancy Category: C

    Lactation: unknown

    Adults

    1 applicatorful (20 or 40 mg terconazole/5 g cream) intravaginally/day; 1 suppository (80 mg terconazole) intravaginally/day.

    Geriatric

    1 applicatorful (20 or 40 mg terconazole/5 g cream) intravaginally/day; 1 suppository (80 mg terconazole) intravaginally/day.

    Adolescents

    Safety and efficacy have not been established; however, 1 applicatorful (20 or 40 mg terconazole/5 g cream) intravaginally/day and 1 suppository (80 mg terconazole) intravaginally/day have been used off-label.

    Children

    Safety and efficacy have not been established.

    Infants

    Safety and efficacy have not been established.

    Neonates

    Safety and efficacy have not been established.

    Terconazole

    vaginal cream

    • 0.4%
    • 0.8%

    suppository

    • 80mg