Classes
DEA Class; Rx
Common Brand Names; OptiPranolol (DSC)
- Antiglaucoma, Beta-Blockers
Description
Ophthalmic, non-selective beta-blocker used for open-angle glaucoma or ocular hypertension. Similar to timolol.
Indications
Indicated for the reduction of elevated intraocular pressure (IOP) in patients with open angle glaucoma or ocular hypertension.
Contraindications
Hypersensitivity
Asthma, uncompensated CHF, severe COPD, symptomatic sinus bradycardia, 2nd or 3rd degree AV block, cardiogenic shock
Adverse Effects
Ocular
- Burning sensation in eye
- Blepharitis
- Blurred vision
- Light intolerance
- Uveitis
- Tearing
- Eyelid dermatitis
- Browache
Systemic
- Similar to systemic beta-blockers including bradycardia, aggravation of CHF, nausea, asthma, nightmares, impotence, tiredness, cough, dyspnea, epistaxis, rhinitis, myalgia, arthritis, rash
- Reduction of systemic side effects by putting finger in corner of eye (occluding punctum) or by gentle eyelid closure (without opening & closing lid) for 3 min
Warnings
Caution in diabetes (may mask signs of hypoglycemia)
Caution on inadequate cardiac function, latent cardiac insufficiency, cerebrovascular insufficiency, sick sinus syndrome, peripheral vascular disease, history of psychiatric illness, heart failure, diminished pulmonary function, nonallergic bronchospasm, diabetes mellitus, myasthenia gravis
Patients receiving topical levobunolol & a systemic ß-adrenergic blocking agent concomitantly should be observed carefully for potential additive effects on IOP &/or systemic effects of ß-adrenergic blockade
May mask signs of hyperthyroidism (ie, tachycardia)
Remove contact lens prior to administration
Pregnancy and Lactation
Pregnancy Category: C
Lactation: Excretion in breast milk unknown; use caution
Maximum Dosage
2 drops/day per affected eye.
2 drops/day per affected eye.
Safe and effective use has not been established.
Safe and effective use has not been established.
How supplied
Metipranolol
ophthalmic solution
- 0.3%