Isradipine

DEA Class; Rx

Common Brand Names; DynaCirc

•  Calcium Channel Blockers; 
• Calcium Channel Blockers, Dihydropyridine

Indicated for the treatment of hypertension.

Hypersensitivity to isradipine or other calcium channel blockers; hypotension (<90 mm Hg systolic)

• Headache (2-22%)
• Edema (1-9%)
• Dizziness (2-8%)
• Palpitation (1-5%)
• Flushing (1-5%)
• Tachycardia (1-3%)
• Chest pain (2-3%)
• Rash (2%)
• Nausea (1-5%)
• Vomiting (≤1%)
• Diarrhea (≤ 3%)
• Weakness (≤1%)
• Dyspnea (1-3%)
• Urinary frequency (1-3%)
• Drug-induced gingival hyperplasia
• Angioedema
• Drowsiness
• Hyperhidrosis
• Leg pain
• Nasal congestion
• Drug fever
• Dysuria
• Impotence
• Pruritus
• Urticaria
• Weight gain
• Myocardial infarction

Use caution in CHF, aortic stenosis, hypotension (initially or after dose increases), persistent progressive dermatologic reactions, exacerbation of angina (during initiation of treatment, after dose increase, or withdrawal of beta blocker), liver impairment

Reflex tachycardia resulting in angina and/or MI in patients with obstructive coronary disease reported

Peripheral edema may occur within 2-3 weeks of initiating therapy

Hypotension with or without syncope is possible (particularly with severe aortic stenosis)

Avoid taking with grapefruit juice

Pregnancy Category: C

Lactation: not known if excreted into breast milk