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Etodolac

    Generic Only

    DEA Class; Rx

    Common Brand Names; Lodine

    NSAID

    NSAID; has analgesic and antipyretic properties; a difluorophenyl derivative of salicylic acid; not metabolized to salicylic acid; may interfere with some salicylate assays resulting in falsely elevated salicylate levels; for osteoarthritis and rheumatoid arthritis and relief of mild to moderate pain; causes an increased risk of serious gastrointestinal adverse effects; may cause an increased risk of serious cardiovascular events; use lowest effective dose for the shortest possible duration.

    For the treatment of mild pain and moderate pain.

    Used for the treatment of osteoarthritis or rheumatoid arthritis.

    Absolute: hypersensitivity to diflunisal, ASA allergy, history of aspirin triad, CABG

    Relative: bleeding disorders, duodenal/gastric/peptic ulcer, renal impairment, stomatitis, ulcerative colitis, upper GI dz, late pregnancy (risk of premature closure of ductus arteriosus)

    >10%

    Increased liver function test (up to 15%)

    1-10%

    Body fluid retention

    Rash

    Abdominal pain

    Constipation

    Diarrhea

    Flatulence

    Indigestion

    Nausea

    Dizziness

    Headache

    Insomnia

    Tinnitus

    Use caution in bronchospasm, cardiac disease, CHF, hepatic/renal impairment, HTN, SLE, fluid retention, >65 years

    Potential risk of cardiovascular damage

    Long-term administration of NSAIDs may result in renal papillary necrosis and other renal injury; patients at greatest risk include the elderly, or those with impaired renal function, hypovolemia, heart failure, liver dysfunction, salt depletion, and individuals taking diuretics, ACE inhibitors, or ARBs

    Risk of serious skin reactions

    Pregnancy Category: C (avoid in late pregnancy; may cause premature closure of ductus arteriosus)

    Lactation: enters breast milk/not recommended

    Adults

    1,500 mg/day PO.

    Geriatric

    1,500 mg/day PO.

    Adolescents

    1,500 mg/day PO.

    Children

    12 years: 1,500 mg/day PO.

    1 to 11 years: Safety and efficacy have not been established.

    Infants

    Safety and efficacy have not been established.

    Neonates

    Safety and efficacy have not been established.

    Tablet

    • 500mg