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Dopamine

    Brands

    DEA Class;  Rx

    Common Brand Names; Intropin

    • Inotropic Agents

    Dopamine/Dopamine Hydrochloride/Dopamine Hydrochloride, Dextrose/Dopamine, Dextrose/Intropin Intravenous Inj Sol: 1mL, 40mg, 80mg, 160mg, 200-5%, 400-5%, 800-5%

    Indicated For hemodynamic support or treatment of hypotension during distributive shock (e.g., septic shock, cardiogenic shock, anaphylactic shock, neurogenic shock), open-heart surgery, or renal failure.

    For the treatment of chronic heart failure.

    For the treatment of symptomatic bradycardia unresponsive to atropine and/or external pacing.

    For the treatment of hypotension that may occur after return of spontaneous circulation during cardiopulmonary resuscitation after cardiac arrest.

    Hypersensitivity to dopamine, pheochromocytoma, ventricular fibrillation, uncorrected tachyarrhythmias

    • Cardiovascular: Ventricular arrhythmia, atrial fibrillation (at very high doses), ectopic beats, tachycardia, anginal pain, palpitation, cardiac conduction abnormalities, widened QRS complex, bradycardia, hypotension, hypertension, vasoconstriction
    • Respiratory: Dyspnea
    • Gastrointestinal: Nausea, vomiting
    • Metabolic/nutritional: Azotemia
    • Central nervous system: Headache, anxiety
    • Endocrine: Piloerection
    • Ocular: Increased intraocular pressure; dilated pupils
    • Gangrene of extremities has occurred when high doses were administered for prolonged periods or in patients with occlusive vascular disease receiving low doses of dopamine hydrochloride

    Use caution in angina pectoris, extravasation, hypovolemia, occlusive vascular disease, ventricular arrhythmias, recent use of monoamine oxidase inhibitors, sensitivity to sulfites

    Drug is inactivated by alkali

    May cause increases in heart rate

    Use with caution after myocardial infarction

    Monitor blood pressure closely

    Use caution in patients taking MAO inhibitors; prolong hypertension may occur with concurrent use

    Pregnancy category: C

    Lactation: Unknown whether drug is excreted into breast milk; use caution

    Adults

    50 mcg/kg/minute continuous IV infusion.

    Geriatric

    50 mcg/kg/minute continuous IV infusion.

    Adolescents

    20 mcg/kg/minute continuous IV infusion.

    Children

    20 mcg/kg/minute continuous IV infusion.

    Infants

    20 mcg/kg/minute continuous IV infusion.

    Neonates

    20 mcg/kg/minute continuous IV infusion.

    Dopamine hydrochloride

    infusion solution, in D5W

    • 80mg/100mL
    • 160mg/100mL
    • 320mg/100mL

    injectable solution

    • 40mg/mL
    • 80mg/mL
    • 160mg/mL