Skip to content

Dacarbazine

    Brands

    DEA Class; Rx

    Common Brand Names; DTIC Dome

    • Antineoplastics, Alkylating

    Alkylating antineoplastic agent; used in the treatment of melanoma, sarcoma, and Hodgkin’s disease.

    Indicated for the treatment of metastatic malignant melanoma.

    For the treatment of Hodgkin lymphoma.
    For the treatment of unresectable or metastatic osteogenic sarcoma, in combination with mesna, ifosfamide, and doxorubicin.
    For the treatment of of unresectable or metastatic Ewing’s sarcoma, in combination with mesna, ifosfamide, and doxorubicin.

    Hypersensitivity

    Breastfeeding

    Severe anemia, severe thrombocytopenia

    • Nausea (>90%)
    • Vomiting(>90%)
    • Injection site pain
    • Leukopenia
    • Thrombocytopenia
    • Alopecia
    • Rash
    • Photosensitivity
    • Anorexia
    • Metallic taste
    • Flu-like syndrome

    Caution in hepatic/renal impairment; monitor for toxicity

    May cause severe pain & burning at injection site & along vein; to alleviate, may increase diluent, reduce infusion rate & apply cold compresses

    Risk of potentially fatal hepatocellular necrosis

    Avoid pregnancy

    Pregnancy Category: C

    Lactation: not known if excreted in breast milk, do not nurse

    Adults

    1000 mg/m2 IV as a single dose.

    Elderly

    1000 mg/m2 IV as a single dose.

    Adolescents

    375 mg/m2 IV as a single dose; single doses of 900 mg/m2 IV have been given off-label for neuroblastoma.

    Children

    375 mg/m2 IV as a single dose; single doses of 900 mg/m2 IV have been given off-label for neuroblastoma.

    Dacarbazine

    powder for injection

    • 100mg
    • 200mg