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    DEA Class;  Rx

    Common Brand Names; Aricept, Aricept ODT

    • Acetylcholinesterase Inhibitors, Central

    Reversible cholinesterase inhibitor (ChEI); available in oral and transdermal system formulations
    Approved for symptom management of mild to severe Alzheimer’s diseasen adults; may provide cognitive benefit in mixed dementia and dementia with Lewy bodies
    In patients with risk factors for QT prolongation and torsade de pointes (TdP) consider risk:benefit because of the risk for QT prolongation

    Indicated for dementia of the Alzheimer type

    For the treatment of vascular dementia.

    For the treatment of dementia with Lewy bodies

    Hypersensitivity to donepezil or to piperidine derivatives


    • Nausea (3-19%)
    • Diarrhea (5-15%)
    • Insomnia (2-14%)
    • Accident (7-13%)
    • Infection (11%)


    • Headache (3-10%)
    • Vomiting (3-8%)
    • Cramping (3-8%)
    • Fatigue (3-8%)
    • Anorexia (2-8%)
    • Hypertension (3% )
    • Abnormal dreams (3%)
    • Hallucinations (3%)
    • Confusion (2%)
    • Syncope (2%)

    Risk of GI bleed, especially in patients with history of gastric ulcer or those on NSAIDs

    Cholinesterase inhibitors are likely to exaggerate succinylcholine-type muscle relaxation during anesthesia

    Cholinesterase inhibitors may have vagotonic effects on the sinoatrial and atrioventricular nodes manifesting as bradycardia or heart block

    Can cause vomiting (higher risk with dose of 23 mg/day)

    May cause anorexia and/or weight loss (dose dependent)

    Cholinomimetics may cause bladder outflow obstructions

    Cholinomimetics are believed to have some potential to cause generalized convulsions

    Pregnancy Category: C

    Lactation: There are no data on presence of donepezil or metabolites in human milk, effects on breastfed infant, or on milk production


    23 mg/day PO; 10 mg/day transdermally.


    23 mg/day PO; 10 mg/day transdermally.


    Not indicated.


    Not indicated.


    • 5mg
    • 10mg
    • 23mg

    Tablet, oral disintegrating

    • 5mg
    • 10mg

    Transdermal system

    • 5mg/day
    • 10mg/day