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Dipyrone (metamizole)

    Dipyrone (Metamizole) Uses
    Brands

    Dipyrone (metamizole) is a pyrazolone analgesic and antipyretic drug, now seldom used because of its side effects.

    DAE Class; Rx

    Common Brand Names; NOVALGINE

    Dipyrone (metamizole) is a pyrazolone analgesic and antipyretic drug, now seldom used because of its side effects. Dipyrone is NSAID (non-steroidal anti-inflammatory drug). It is used in severe pain when no alternative is available

    Dipyrone (metamizole) is primarily used in conditions like Biliary colic, Genitourinary tract colic, Headache, Muscular spasm, Neoplasms, Pain, Refractory pyrexia, Rheumatic diseases, Toothache, Trauma, and can also be given in adjunctive therapy as an alternative drug of choice in Surgery.

    Metamizole is banned in several countries, where it was previously used as a powerful analgesic and fever reducer. In countries where it is still available, metamizole is indicated for acute severe pain after injuries or surgeries, colic, tumor pain, and acute or severe pain symptoms, as well as high fever if other treatments are unsuccessful.

    Dipyrone is contraindicated in conditions like G6pd deficiency, Hepatic porphyria.

    The severe or irreversible side effects of Dipyrone (metamizole), which give rise to further complications include Agranulocytosis, Blood dyscrasias, Shock.

    The symptomatic adverse reactions produced by Dipyrone are more or less tolerable and if they become severe, they can be treated symptomatically, these include Rashes, Urticaria, Asthma, Pain at injection site.

    Dipyrone (metamizole) should be used with caution in asthmatic patients, in neonates and during pregnancy.

    Drug should not be given to Pregnant Mothers, and Neonates.

    Drug should not be given to Pregnant Mothers.

    Intramuscular, Intravenous
    Fever, Severe pain

    Adult: As metamizole Na: 1 g up to 4 times daily or 2.5 g bid given via IV inj over 5 minutes or via IM inj. Adjust dose based on severity and patient response. Max: 5 g daily.
    Child: As methimazole Na: ≥3 months Dosage varies based on body weight. Refer to individual product literature for detailed guidelines.


    Oral
    Fever, Severe pain

    Adult: As metamizole Na: 0.5-1 g up to 3-4 times daily. Max: 4 g daily. Max treatment duration: 3-5 days.
    Child: As methimazole Na drops: ≥3 months Dosage varies based on body weight. Recommended dose: 8-16 mg/kg as single dose, may repeat if necessary, up to 3 or 4 times daily. Refer to individual product literature for detailed guidelines.

    Dipyrone (metamizole) dosage form and strenght

    Injection: 250 mg/ml, 500 mg/ml,
    Drops: 500 mg/ml,
    Syrup: 50 mg/5ml, 250 mg/5ml,
    Tablets: 50 mg, 500 mg,