Skip to content

Dipyridamole

    Brands

    DEA Class; Rx

    Common Brand Names; Persantine

    • Antiplatelet Agents, Cardiovascular; 
    • Antiplatelet Agents, Hematologic

    Oral, P2Y12 platelet inhibitor
    Used for rate reduction of myocardial infarction (MI) and stroke in patients with non-ST-elevation acute coronary syndromes, STEMI, established peripheral arterial disease, or recent MI or stroke
    Associated with diminished antiplatelet effect in CYP2C19 poor metabolizers

    Indicated for arterial thromboembolism prophylaxis.

    For use in coronary artery disease diagnosis (i.e., dipyridamole stress echocardiography) as an adjunct to thallium myocardial perfusion imaging.
    For secondary prophylaxis of transient ischemic attack (TIA) in combination with aspirin.
    For the treatment of dilated cardiomyopathy.
    For the treatment of proteinuria associated with membranous glomerulonephritis.
    For myocardial infarction prophylaxis in patients who have sustained a prior myocardial infarction (MI).

    Hypersensitivity

    Thrombocytopenia

    • Chest pain (20%)
    • Angina exacerbation, IV (19.7%)
    • Abnormal ECG (15.9%)
    • Headache, IV (12.2%)
    • Dizziness (12%)
    • ST-T changes (7.5%)
    • Abdominal discomfort, oral (6.1%)
    • Extrasystole (5%)
    • Nausea, IV (4.6%)
    • Hypotension, IV (4.6%)
    • Flushing (3.4%)
    • Generalized pain (2.6%)
    • Headache, oral (2.3%)
    • Myocardial infarction (rare)
    • Ventricular arrhythmia (rare)
    • Bronchospasm (rare)
    • Dyspnea

    FDA approval for chronic angina withdrawn (not useful according to most experts)

    Dipyridamole has a vasodilatory effect and should be used with caution in patients with severe coronary artery disease (eg, unstable angina or recently sustained myocardial infarction); chest pain may be aggravated in patients with underlying coronary artery disease who are receiving drug

    Elevations of hepatic enzymes and hepatic failure reported in association with therapy administration

    Drug should be used with caution in patients with hypotension since it can produce peripheral vasodilation

    Pregnancy Category: B

    Lactation: enters breast milk; use with caution

    Adults

    400 mg/day PO.

    Elderly

    400 mg/day PO.

    Adolescents

    400 mg/day PO.

    Children

    Specific maximum dosage information is not available.

    Dipyridamole

    injectable solution

    • 5mg/mL

    tablet

    • 25mg
    • 50mg
    • 75mg