General Description
Synonyms: Acetdimethylamide; acetic acid dimethylamide; acetyldimethylamine; dimethylacetamidum; dimethylacetone amide; dimethylamide acetate; DMA; DMAC.
Description: Dimethylacetamide occurs as a clear, colorless, slightly hygroscopic liquid. It has a weak ammonia-like or fish-like odor
Chemical Name: N,N-Dimethylacetamide
Uses
Dimethylacetamide is used as a solvent in oral and injectable pharmaceutical formulations.
It has been used as a cosolvent to solubilize poorly soluble drugs.
The use of dimethylacetamide has also been investigated as a vehicle for the parenteral delivery of relatively small peptides.
The use of solvents such as dimethylacetamide has been shown to influence the size and rate of release of norfloxacin from nanoparticles
Dimethylacetamide has also been used in topical formulations and has been evaluated as a permeation enhancer for transdermal drug delivery
Incompatibilities
Dimethylacetamide is incompatible with carbon tetrachloride, oxidizing agents, halogenated compounds, and iron. It attacks plastic and rubber. Contact with strong oxidizers may cause fire.
Safety
Dimethylacetamide is used in pharmaceutical preparations as a solvent in parenteral formulations and is generally regarded as a nontoxic material when used as an excipient. Animal toxicity studies indicate that dimethylacetamide is readily absorbed into the bloodstream following inhalation or topical application. Repeated exposure to dimethylacetamide may be harmful and can result in liver damage. High intravenous doses (>400 mg/kg/day for 3 days) may be hallucinogenic.
Handling Precautions
Observe normal precautions appropriate to the circumstances and quantity of the material handled. Dimethylacetamide can be absorbed into the bloodstream by inhalation and through the skin; it is irritating to the skin and eyes.