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Diloxanide Furoate

    Brands

    DEA Class; Rx

    Common Brand Names; 

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    Diloxanide can usually be given alone for chronic intestinal amoebiasis, but should be used as an adjunct to metronidazole or tinidazole acute intestinal amoebiasis.

    Amoebiasis – acute intestinal: adjunctive treatment
    Amoebiasis – intestinal chronic : treatment

    Breastfeeding
    Pregnancy

    Side effects include flatulence, itchiness, and hives. In general, the use of diloxanide is well tolerated with minimal toxicity. Although there is no clear risk of harm when used during pregnancy, diloxanide should be avoided in the first trimester if possible

    Diloxanide furoate is not recommended in women who are breast feeding, and in children <2 years of age

    Children weighing less than 25kg

    Diloxanide furoate is contraindicated in pregnancy.

    Diloxanide furoate is contraindicated in breastfeeding.

    Diloxanide can usually be given alone for chronic intestinal amoebiasis, but should be used as an adjunct to metronidazole or tinidazole acute intestinal amoebiasis.

    Adults

    500mg three times a day for ten days.
    If required, a second course of treatment may be prescribed.

    Children

    Children 25kg and over
    20mg/kg daily, in divided doses for ten days.
    If required, a second course of treatment may be prescribed.

    The following alternative dosing schedule may be suitable:
    Children aged 12 to 18 years (less than 25kg – unlicensed)
    500mg three times a day for ten days.

    Children aged 1 month to 12 years (less than 25kg – unlicensed)
    6.6mg/kg three times a day for ten days.

    diloxanide furoate 500mg tablets