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Dicloxacillin

    Generic Only

    DEA Class; Rx

    Common Brand Names; Dynapen

    • Penicillins, Penicillinase-Resistant

    Oral semisynthetic isoxazolyl antistaphylococcal penicillin. Most active of the isoxazolyl antistaphylococcal penicillins. Stable against penicillinase and active against many of the penicillinase-producing strains of Staphylococcus aureus. Clinical uses include skin and soft-tissue, bone and joint, respiratory tract, and urinary tract infections.

    Indicated for Staphylococcus aureus infections

    Indicated for the treatment of mastitis.

    For the treatment of skin and skin structure infections, including impetigo, cellulitis, erysipelas, animal bite wounds, and diabetic foot ulcer.
    For the treatment of peritoneal dialysis catheter-related infection.

    Hypersensitivity to penicillins, cephalosporins, imipenem

    Initial treatment of severe infections

    Concomitant live bacterial vaccines

    • Abdominal pain
    • Diarrhea
    • Nausea
    • Anemia
    • Elevated LFTs
    • Fever
    • Hypersensitivity
    • Nephritis
    • Pseudomembranous colitis
    • Seizures with extremely high doses &/or renal failure
    • Rash (maculopapular to exfoliative)
    • Vomiting
    • Vaginitis

    Monitor PT if patient is taking warfarin concurrently

    Prolonged use may result in superinfection

    Elimination of drug in neonates is slow; use caution

    Pregnancy Category: B

    Lactation: excreted in breast milk, use caution

    Adults

    1 g/day PO per FDA-approved labeling; however, doses up to 2 g/day PO have been used off-label.

    Geriatric

    1 g/day PO per FDA-approved labeling; however, doses up to 2 g/day PO have been used off-label.

    Adolescents

    25 mg/kg/day PO (Max: 1 g/day) per FDA-approved labeling; however, doses up to 50 mg/kg/day PO (Max: 2 g/day) have been used off-label.

    Children

    25 mg/kg/day PO (Max: 1 g/day) per FDA-approved labeling; however, doses up to 50 mg/kg/day PO (Max: 2 g/day) have been used off-label.

    Dicloxacillin

    capsule

    • 250mg (generic)
    • 500mg (generic)