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Dibutyl Sebacate

    Synonyms:  Bis(n-butyl)sebacate; butyl sebacate; DBS; decanedioic acid, dibutyl ester; dibutyl decanedioate; dibutyl 1,8-octanedicarboxylate; Kodaflex DBS; Morflex DBS.

    Description: Dibutyl sebacate is a clear, colorless, oily liquid with a bland to slight butyl odor.

    Chemical Name: Decanedioic acid, di-n-butyl ester

    • Dibutyl sebacate is used in oral pharmaceutical formulations as a plasticizer for film coatings on tablets, beads, and granules, at concentrations of 10–30% by weight of polymer.

    • It is also used as a plasticizer in controlled-release tablets and microcapsule preparations.

    • Dibutyl sebacate is also used as a synthetic flavor and flavor adjuvant in food products; for example, up to 5 ppm is used in ice cream and nonalcoholic beverages.

    Dibutyl sebacate is incompatible with strong oxidizing materials and strong alkalis.

    Dibutyl sebacate is used in cosmetics, foods, and oral pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material. Following oral administration, dibutyl sebacate is metabolized in the same way as fats. In humans, direct eye contact and prolonged or repeated contact with the skin may cause very mild irritation. Acute animal toxicity tests and long-term animal feeding studies have shown no serious adverse effects to be associated with orally administered dibutyl sebacate.

    Observe normal precautions appropriate to the circumstances and quantity of material handled. It is recommended that eye protection be used at all times. When heating this product, it is recommended to have a well-ventilated area, and the use of a respirator is advised.