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Dextromethorphan/Pseudoephedrine/Guaifenesin

    Brands

    DEA Class; Rx

    Common Brand Names; Capmist DM Tablets, ExeFen DMX Tablets

    • Cough/Cold, Non-narcotic Combos; 
    • Antitussive/Decongestant/Expectorant Combos

    Dextromethorphan is a cough suppressant that acts centrally on the cough center in the medulla.

    Guaifenesin increases respiratory tract fluid secretions and helps to loosen phlegm and bronchial secretions.

    Pseudoephedrine stimulates the alpha-adrenergic receptors causing bronchodilation and vasoconstriction.

    Indicated for Temporary Relief of Nasal Congestion & Cough Due to Bronchial Irritation

    Contraindicated in documented hypersensitivity to the drugs or within 14 days of MAO inhibitor therapy; known G-6-PD deficiency

    • Arrhythmia
    • Palpitations
    • Convulsion
    • Dizziness
    • Headache
    • Drowsiness
    • Excitability
    • Weakness
    • Tremor
    • Nausea
    • Vomiting

    Caution in cardiovascular disease, diabetes mellitus, prostatic hypertrophy and increased intraocular pressure when taking pseudoephedrine

    Acetaminophen hepatotoxicity possible in chronic alcoholics following various dose levels; severe or recurrent pain or high or continued fever may indicate a serious illness; contained in many OTC products and combined use with these products may result in toxicity due to cumulative doses exceeding recommended maximum dose

    Do not take dextromethorphan for persistent or chronic cough associated with smoking, asthma, or emphysema, or if it is accompanied by excessive phlegm unless directed by a healthcare provider; dextromethorphan may slow the breathing

    Pregnancy Category: C

    Lactation: excretion in milk unknown/contraindicated

    Pregnant or breastfeeding patients should seek advice of health professional before using OTC drugs

    5 mL PO q4-6hr; not to exceed 30 mL/day

    1 tab [(20mg/30mg/400mg)] PO q4-6hr; not to exceed 6 tabs/day

    1 tab [(20mg/40mg/400mg)] PO q4-6hr; not to exceed 6 tabs/day

    Dextromethorphan/pseudoephedrine/guaifenesin

    liquid

    • 10mg/20mg/200mg

    tablet

    • 20mg/30mg/400mg
    • 20mg/20mg/400mg
    • 20mg/60mg/400mg
    • 20mg/40mg/400mg