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Cycloserine

    Brands

    DEA Class; Rx

    Common Brand Names; Capastat

    • Antitubercular Agents

    Bacteriostatic or bactericidal

    Inhibits cell wall synthesis

    Indicated for treatment of Tuberculosis

    Hypersensitivity

    Alcohol use

    Renal dysfunction, severe

    History of seizure disorder, mental depression, severe anxiety or psychosis

    • Confusion
    • Restlessness
    • Drowsiness
    • Vertigo
    • Cardiac arrhythmia
    • Folate deficiency
    • Hyperreflexia
    • Dysarthria
    • Dizziness
    • Headache
    • Coma
    • Liver enzymes increased
    • Somnolence
    • Paresis
    • Seizure
    • Heart failure

    Caution in patients with history of alcoholism (may increase seizures), anemia, impaired hepatic/renal function

    CNS toxicity (depression, seizures, psychosis) may occur

    Prolonged use may result in fungal or bacterial superinfection (C. difficile-associated diarrhea)

    Pregnancy Category: C

    Lactation: enters breast milk; safe

    Active Tuberculosis

    Initial: 250 mg PO q12hr for 14 days THEN

    500 mg -1 g/day divided q12hr for 18-24 months; not to exceed 1 g/day

    Monitor blood levels

    UTI

    Initial: 250 mg PO q12hr for first 14 days

    Maintenance: 500 mg -1 g/day in divided doses; not to exceed 1 g/day

    Monitor blood levels

    Gaucher’s Disease (Orphan)

    Orphan indication sponsor

    • Lev, Meir M.D.; The City College, City University Of NY Medical Sc, Convent Avenue at 138 Street; New York, NY 10031

    Cycloserine

    capsule

    • 250mg