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Cyclizine

    Brands

    DEA Class; OTC

    Common Brand Names; Marezine, Bonine for Kids, Cyclivert

    • Antiemetics, Antihistamine

    Cyclizine is a piperazine derivative that has antiemetic, anticholinergic, and antihistaminic properties; reduces the sensitivity of the labyrinthine apparatus and has central actions on the chemoreceptor trigger zone

    Indicated for the prevention and treatment of nausea, vomiting and vertigo associated with motion sickness

    Hypersensitivity

    Do not use in patients with asthma, glaucoma, emphysema, chronic pulmonary disease, shortness of breath, difficulty in breathing or difficulty in urination due to enlargement of the prostate gland unless directed by a doctor

    Cyclizine should not be used concurrently with sedatives, tranquilizers, or anticholinergic medications

    • Drowsiness
    • Xerostomia
    • Headache
    • Dermatitis
    • Nausea
    • Urinary retention
    • Diplopia
    • Polyuria

    May have hypotensive effects, which may be confusing or dangerous in postoperative patients

    May produce drowsiness; caution while driving or performing other tasks requiring alertness

    Pregnancy Category: B

    Lactation: unknown

    Adults

    50 mg PO taken 30 minutes before departure, may repeat in 4-6 hours if needed, up to 200 mg/day

    Geriatric

    50 mg PO taken 30 minutes before departure, may repeat in 4-6 hours if needed, up to 200 mg/day

    Pediatric

    6-12 years: 25 mg PO up to 3 times/day; not to exceed 75 mg/day

    >12 years: 50 mg PO taken 30 minutes before departure, may repeat in 4-6 hr if needed, up to 200 mg/day

    Cyclizine

    tablet

    • 25mg
    • 50mg