Crospovidone

Synonyms:  Crospovidonum; Crospopharm; crosslinked povidone; E1202; Kollidon CL; Kollidon CL-M; Polyplasdone XL; Polyplasdone XL-10; polyvinylpolypyrrolidone; PVPP; 1-vinyl-2-pyrrolidinone homopolymer.

Description: Crospovidone is a white to creamy-white, finely divided, freeflowing, practically tasteless, odorless or nearly odorless, hygroscopic powder

Chemical Name: 1-Ethenyl-2-pyrrolidinone homopolymer

Tablet disintegrant.

• Crospovidone is a water-insoluble tablet disintegrant and dissolution agent used at 2–5% concentration in tablets prepared by directcompression or wet- and dry-granulation methods.

• It rapidly exhibits high capillary activity and pronounced hydration capacity, with little tendency to form gels.

• Studies suggest that the particle size of crospovidone strongly influences disintegration of analgesic tablets.

• Larger particles provide a faster disintegration than smaller particles. Crospovidone can also be used as a solubility enhancer.

• With the technique of co-evaporation, crospovidone can be used to enhance the solubility of poorly soluble drugs.

• The drug is adsorbed on to crospovidone in the presence of a suitable solvent and the solvent is then evaporated.

• This technique results in faster dissolution rate.

Crospovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to a high water level, crospovidone may form molecular adducts with some materials; see Povidone.

Crospovidone is used in oral pharmaceutical formulations and is generally regarded as a nontoxic and nonirritant material. Shortterm animal toxicity studies have shown no adverse effects associated with crospovidone.

Observe normal precautions appropriate to the circumstances and quantity of material handled. Eye protection, gloves, and a dust mask are recommended.

Copovidone; povidone.