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    Synonyms:  Acetic acid vinyl ester, polymer with 1-vinyl-2-pyrrolidinone; copolymer of 1-vinyl-2-pyrrolidone and vinyl acetate in a ratio of 3 : 2 by mass; copolyvidone; copovidonum; Kollidon VA 64; Luviskol VA; Plasdone S-630; poly(1-vinylpyrrolidone-co-vinyl acetate); polyvinylpyrrolidone-vinyl acetate copolymer; PVP/VA; PVP/VA copolymer.


    Description:  Copovidone is a white to yellowish-white amorphous powder. It is typically spray-dried with a relatively fine particle size. It has a slight odor and a faint taste.

    Chemical Name: Acetic acid ethenyl ester, polymer with 1-ethenyl-2 pyrrolidinone

    Film-forming agent; granulation aid; tablet binder.

    • Copovidone is used as a tablet binder, a film-former, and as part of the matrix material used in controlled-release formulations.

    • In tableting, copovidone can be used as a binder for direct compression and as a binder in wet granulation.

    • Copovidone is often added to coating solutions as a film-forming agent.

    • It provides good adhesion, elasticity, and hardness, and can be used as a moisture barrier

    Copovidone is compatible with most organic and inorganic pharmaceutical ingredients. When exposed to high water levels, copovidone may form molecular adducts with some materials; see Crospovidone and Povidone.

    Copovidone is used widely in pharmaceutical formulations and is generally regarded as nontoxic. However, it is moderately toxic by ingestion, producing gastric disturbances. It has no irritating or sensitizing effects on the skin

    Observe normal precautions appropriate to the circumstances and quantity of material handled. When heated to decomposition, copovidone emits toxic vapors of NOx. Eye protection, gloves, and a dust mask are recommended

    Crospovidone; povidone.