Classes
DEA Class; Rx
Common Brand Names; Colestid
- Bile Acid Sequestrants
Description
Oral bile acid resin; similar to cholestyramine in its cholesterol-lowering effects.
Indications
Indicated for the treatment of primary hypercholesterolemia and hyperlipoproteinemia as an adjunct to diet to reduce elevated total-C and LDL-C.
Contraindications
Hypersensitivity to colestipol
Bowel obstruction
Adverse Effects
- Gastrointestinal (mostly)
- Constipation
- Stomach pain
- Belching
- Nausea/vomiting
- Flatulance
- Diarrhea
- Dizziness
- Anxiety
- Vertigo
- Fatigue
- Drowsiness
- Heartburn
- Steatorrhea
- Malabsorption of fat-soluble vitamins
- Gallstones
- Dysphagia
- GI bleeding
- Cholecystitis
- Peptic ulceration
- Transient esophageal obstruction
Warnings
Increased risk of bleeding due to hypoprothrombinemia from vitamin K deficiency
May interfere with fat absorption, and decrease absorption of fat-soluble vitamins (A, D, E, K)
May worsen pre-existing constipation
Take other medications 1 hr before or 4 hr after colestipol
If significant increase in triglycerides, consider dose reduction, discontinuation or alternatives
Pregnancy and Lactation
Pregnancy Category: C
Lactation: use caution; may interfere with vitamin absorption in infants
Maximum Dosage
30 g/day PO colestipol granules or 16 g/day PO colestipol tablets.
30 g/day PO colestipol granules or 16 g/day PO colestipol tablets.
Safety and efficacy have not been established; 15 g/day PO has been used safely for hypercholesterolemia.
7—12 years: Safety and efficacy have not been established; 15 g/day PO has been used safely for hypercholesterolemia.
< 7 years: Safety and efficacy have not been established.
How supplied
Colestipol hydrochloride