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Clotrimazole

    Brands

    DEA Class; Rx, OTC

    Common Brand Names; Gyne-Lotrimin-3 Combination Pack, Gyne-Lotrimin-3 Vaginal Cream, Gyne-Lotrimin-3 Vaginal Suppositories, Gyne-Lotrimin-7, Mycelex-7, Mycelex-7 Combination Pack, Mycelex vaginal, Gyne Lotrimin, Lotrimin, Lotrimin AF, Mycelex topical

    • Antifungals,
    • Topical

    Imidazole antifungal agent marketed in a variety of preparations including vaginal suppositories and cream, topical lotion and cream, topical solution, and lozenges. Used for infections due to pathogenic dermatophytes, yeasts, and Malassezia furfur including ringworm (dermatophytosis), vaginal and oral candidiasis, and tinea infections. Not indicated for subcutaneous mycoses.

    Indicated for the treatment of cutaneous candidiasis.
    For the treatment of oropharyngeal candidiasis (thrush).
    For oropharyngeal candidiasis prophylaxis in patients immunocompromised by chemotherapy, radiotherapy, or corticosteroid therapy in the treatment of leukemia, solid tumors, or renal transplant.
    For the treatment of vulvovaginal candidiasis (VVC).
    For the treatment of tinea corporis, tinea cruris, and tinea pedis.
    For the treatment of tinea versicolor.

    Hypersensitivity

    Abnl LFTs

    Nausea/vomiting (troches)

    Mild burning, irritation, stinging to skin or vaginal area (vaginal tabs/cream)

    Abnormal LFTs reported, including abnormal aspartate aminotransferase reported; monitor LFTs periodically, especially in patients with hepatic impairment

    Use caution; abnormal LFTs reported; elevation usually minimal; monitor LFTs periodically

    Not for treatment of systemic fungal infections

    For maximum efficacy, must dissolve dosage form in mouth

    Pregnancy category: C

    Lactation: Excretion in milk unknown; use with caution

    Adults

    50 mg/day PO; 1 applicatorful (50 or 100 mg clotrimazole/5 g cream) intravaginally/day. Maximum dosage not available for topical products.

    Geriatric

    50 mg/day PO; 1 applicatorful (50 or 100 mg clotrimazole/5 g cream) intravaginally/day. Maximum dosage not available for topical products.

    Adolescents

    50 mg/day PO; 1 applicatorful (50 or 100 mg clotrimazole/5 g cream) intravaginally/day. Maximum dosage not available for topical products.

    Children

    12 years: 50 mg/day PO; 1 applicatorful (50 or 100 mg clotrimazole/5 g cream) intravaginally/day. Maximum dosage not available for topical products.
    3 to 11 years: 50 mg/day PO. Maximum dosage not available for topical products. Safety and efficacy of other formulations have not been established.
    1 to 2 years: Maximum dosage not available for topical products. Safety and efficacy of other formulations have not been established.

    Infants

    Safety and efficacy have not been established.

    Neonates

    Safety and efficacy have not been established.

    Clotrimazole

    troche

    • 10mg

    lozenge

    • 10mg

    topical cream/ointment/solution

    • 1%

    vaginal cream

    • 1%
    • 2%