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Clonidine/Chlorthalidone

    Brands

    DEA Class;  Rx

    Common Brand Names; Clorpres

    • Thiazide Combos

    Combination thiazide diuretic (chlorthalidone) and centrally acting alpha2 adrenergic agonist (clonidine).
    Used for hypertension, but not for initial therapy; used if fixed dose represents effective dosages for the patient after titration.
    The fixed combination may be more convenient than taking each drug individually.

    Indicated for the treatment of hypertension.
    NOTE: Clonidine; chlorthalidone fixed combination therapy is not indicated for initial antihypertensive therapy. The initial dose must be titrated to the individual patient. If the fixed combination represents the individual dosages required for the patient, its use may be more convenient in patient management.

    Hypersensitivity to either component or sulfonamide derivatives

    No adverse effects specific to the combination have been observed; adverse effects limited to those previously reported with clonidine and chlorthalidone

    Clonidine

    • Orthostatic hypotension
    • Bradycardia
    • Syncope
    • Arrhythmia
    • Chest pain
    • Atrioventricular block
    • Flushing
    • Drowsiness
    • Fatigue
    • Malaise
    • Rash
    • Anorexia, weight gain
    • Dry mouth
    • Nausea/vomiting
    • Abnormal LFTs

    Chlorthalidone

    • Blurred vision, xanthopsia
    • Constipation
    • Diarrhea
    • Dizziness
    • Electrolyte abnormalities
    • Headache, vasculitis
    • Hyperglycemia
    • Hyperuricemia
    • Hypotension
    • Impotence
    • Loss of appetite
    • Muscular spasticity, restlessness
    • Nausea/vomiting
    • Paresthesia
    • Photosensitivity, phototoxicity

    Bronchospastic disease

    DM, hyperuricemia or gout, hypotension, SLE

    Chlorthalidone may cause fluid or electrolyte imbalance including hyponatremia, hypochloremic alkalosis, or hypokalemia

    History of depression

    Liver disease

    May aggravate digitalis toxicity

    Patients allergic to sulfa may show cross-sensitivity

    May impair ability to perform hazarous tasks

    Risk of male sexual dysfunction

    Renal impairment

    Severe coronary insufficiency, recent MI, conduction disturbances, cerebrovascular disease, chronic renal failure, Raynaud’s disease, thromboangiitis obliteran

    Sudden cessation of clonidine treatment has resulted in subjective symptoms such as nervousness, agitation and headache, accompanied or followed by a rapid rise in blood pressure and elevated catecholamine concentrations in the plasma

    Pregnancy Category: C

    Lactation: excreted in breast milk, use caution

    Adults

    0.6 mg/day PO clonidine; 30 mg/day PO chlorthalidone when used in this combination.

    Geriatric

    0.6 mg/day PO clonidine; 30 mg/day PO chlorthalidone when used in this combination.

    Adolescents

    Safety and efficacy have not been established.

    Children

    Safety and efficacy have not been established.

    Infants

    Use not established.

    Neonates

    Use not established.

    Clonidine hydrochloride/Chlorthalidone

    tablet

    • 0.1mg/15mg
    • 0.2mg/15mg
    • 0.3mg/15mg