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    DEA Class; Rx

    Common Brand Names; Veltin, Ziana

    • Acne Agents, Topical Combos

    Naturally occurring retinoid analog; also known as all-trans-retinoic acid (aTRA)
    Oral form used in acute promyelocytic leukemia; topical form used for cutaneous disorders like acne and photoaging
    Treatment with oral form may cause acute promyelocytic leukemia differentiation syndrome

    Indicated for the treatment of acne vulgaris.

    Hypersensitivity to clindamycin or lincomycin or any of its components

    History of regional enteritis, ulcerative colitis or antibiotic-associated colitis (including pseudomembranous colitis)

    • Erythema (21-35%)
    • Scaling (13-19%)
    • Itching (15-17%)
    • Dryness (6%)
    • Irritation (5%)
    • Exfoliation (5%)
    • Erythema (4%)
    • Pruritus (2%)
    • Stinging (2%)
    • Burning (2%)
    • Sunburn (1%)
    • Dermatitis (1%)

    Systemic absorption of clindamycin has been demonstrated following topical use; discontinue immediately if significant diarrhea occurs

    May cause irritation, especially when used with concomitant topical acne therapy including peeling, desquamating, or abrasive agents

    Should be used with caution in atopic individuals

    For external use only; avoid contact with eyes and mucous membranes; not for oral, ophthalmic or intravaginal use

    Avoid sunlight/UV exposure; wear sunscreen daily

    Do not use with erythromycin-containing products

    Coadministration with topical agents with drying effect can increase skin irriation; caution advised

    Clindamycin can cause severe colitis; discontinue if significant diarrhea occurs

    Pregnancy Category: C

    Lactation: excretion in milk unknown; use with caution


    45 mg/m2 per day PO.


    45 mg/m2 per day PO.


    45 mg/m2 per day PO.


    45 mg/m2 per day PO.


    Safety and efficacy not established.


    Safety and efficacy not established.



    • 1.2%/0.025%