Clindamycin/​Tretinoin

DEA Class; Rx

Common Brand Names; Veltin, Ziana

• Acne Agents, Topical Combos

Naturally occurring retinoid analog; also known as all-trans-retinoic acid (aTRA)
Oral form used in acute promyelocytic leukemia; topical form used for cutaneous disorders like acne and photoaging
Treatment with oral form may cause acute promyelocytic leukemia differentiation syndrome

Indicated for the treatment of acne vulgaris.

Hypersensitivity to clindamycin or lincomycin or any of its components

History of regional enteritis, ulcerative colitis or antibiotic-associated colitis (including pseudomembranous colitis)

• Erythema (21-35%)
• Scaling (13-19%)
• Itching (15-17%)
• Dryness (6%)
• Irritation (5%)
• Exfoliation (5%)
• Erythema (4%)
• Pruritus (2%)
• Stinging (2%)
• Burning (2%)
• Sunburn (1%)
• Dermatitis (1%)

Systemic absorption of clindamycin has been demonstrated following topical use; discontinue immediately if significant diarrhea occurs

May cause irritation, especially when used with concomitant topical acne therapy including peeling, desquamating, or abrasive agents

Should be used with caution in atopic individuals

For external use only; avoid contact with eyes and mucous membranes; not for oral, ophthalmic or intravaginal use

Avoid sunlight/UV exposure; wear sunscreen daily

Do not use with erythromycin-containing products

Coadministration with topical agents with drying effect can increase skin irriation; caution advised

Clindamycin can cause severe colitis; discontinue if significant diarrhea occurs

Pregnancy Category: C

Lactation: excretion in milk unknown; use with caution

45 mg/m2 per day PO.

45 mg/m2 per day PO.

45 mg/m2 per day PO.

45 mg/m2 per day PO.

Safety and efficacy not established.

Safety and efficacy not established.

Clindamycin/tretinoin

gel

• 1.2%/0.025%