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Benzoyl Peroxide/Clindamycin

    DEA Class; Rx

    Common Brand Names; BenzaClin, Acanya, Duac, Onexton

    • Acne Agents, Topical Combos

    Topical combination acne product
    Both drug components exhibit antibacterial activity; benzoyl peroxide has drying actions, sebostatic effects, and causes mild skin desquamation
    Use results in improvements in both inflammatory and non-inflammatory acne lesions

    Indicated for the treatment of acne vulgaris.

    For the treatment of moderate to severe acne rosacea.

    Hypersensitivity to clindamycin, benozyl peroxide, lincomycin or any of the drug components

    History of regional enteritis, ulcerative colitis or antibiotic-associated colitis (including pseudomembranous colitis)

    • Application site pain
    • Application site exfoliation
    • Application site irritation
    • Erythema
    • Burning
    • Pruritus
    • Sunburn
    • Scaling
    • Dryness
    • Diarrhea
    • Colitis
    • Peeling

    Should be used with caution in atopic individuals

    For external use only; avoid contact with eyes and mucous membranes

    Minimize sun expsoure following application

    May have bleaching effects on hair or colored fabric

    Bacterial of fungal superinfection may result from prolonged use

    Concomitant topical acne therapy may result in cumulative irritancy, especially with use of peeling, desquamating, or abrasive agents; if irritancy or dermatitis occurs, reduce frequency of application or temporarily interrupt treatment and resume once irritation subsides; discontinue treatment if irritation persists

    Do not use clindamycin and erythromycin containing products together

    There are no available data on use in pregnant women to evaluate a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes

    There are no data on presence of clindamycin or benzoyl peroxide in human milk, effects on breastfed child, or on milk production following topical administration


    Maximum dosage information not available.


    Maximum dosage information not available.


    Maximum dosage information not available.


    12 years: Maximum dosage information not available.
    < 12 years: Safety and efficacy have not been established.

    Clindamycin/benzoyl peroxide

    topical gel

    • 1%/5% (BenzaClin)
    • 1.2%/2.5% (Acanya)
    • 1.2%/3.75% (Onexton)
    • 1.2%/5% (Duac)