Benzoyl Peroxide/Clindamycin

DEA Class; Rx

Common Brand Names; BenzaClin, Acanya, Duac, Onexton

• Acne Agents, Topical Combos

Topical combination acne product
Both drug components exhibit antibacterial activity; benzoyl peroxide has drying actions, sebostatic effects, and causes mild skin desquamation
Use results in improvements in both inflammatory and non-inflammatory acne lesions

Indicated for the treatment of acne vulgaris.

Hypersensitivity to clindamycin, benozyl peroxide, lincomycin or any of the drug components

History of regional enteritis, ulcerative colitis or antibiotic-associated colitis (including pseudomembranous colitis)

• Application site pain
• Application site exfoliation
• Application site irritation
• Erythema
• Burning
• Pruritus
• Sunburn
• Scaling
• Dryness
• Diarrhea
• Colitis
• Peeling

Should be used with caution in atopic individuals

For external use only; avoid contact with eyes and mucous membranes

Minimize sun expsoure following application

May have bleaching effects on hair or colored fabric

Bacterial of fungal superinfection may result from prolonged use

Concomitant topical acne therapy may result in cumulative irritancy, especially with use of peeling, desquamating, or abrasive agents; if irritancy or dermatitis occurs, reduce frequency of application or temporarily interrupt treatment and resume once irritation subsides; discontinue treatment if irritation persists

Do not use clindamycin and erythromycin containing products together

There are no available data on use in pregnant women to evaluate a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes

There are no data on presence of clindamycin or benzoyl peroxide in human milk, effects on breastfed child, or on milk production following topical administration

Clindamycin/benzoyl peroxide

topical gel

• 1%/5% (BenzaClin)
• 1.2%/2.5% (Acanya)
• 1.2%/3.75% (Onexton)
• 1.2%/5% (Duac)