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Choline Magnesium Trisalicylate

    Brands

    DEA Class; Rx

    Common Brand Names; Trilisate ASA combination

    • NSAIDs

    Inhibits cyclooxygenase; [at least 2 isoenzymes, cyclooxygenase-1 (COX-1) and -2 (COX-2)], thereby inhibiting prostaglandin synthesis

    Indicated for Osteoarthritis, Rheumatoid Arthritis, Fever, Shoulder pain

    Absolute: bleeding disorders, chronic advanced renal insufficiency, GI hemorrhage, hemorrhagic diathesis, salicylate allergy

    Relative: Erosive gastritis, GI ulcer, NOS

    GI pain/ulceration/bleeding

    Tinnitus, hearing loss

    Hepatotoxicity

    Renal damage

    Premature hemolysis

    CNS alteration

    Pulmonary edema (salicylate-induced/noncardiogenic)

    Dermatologic problems, urticaria

    Angioedema

    Bronchospasm

    Anemia, gout, hepatic function impairment, hypertension, hypoprothrombinemia, nasal polyps, renal function impairment, thyrotoxicosis, vitamin K deficiency

    Use of salicylates in pediatric pts with varicella or influenza-like illness is associated with incr incidence of Reye’s Syndrome

    Pregnancy Category: C; D if used for prolonged periods or near term

    Lactation: excreted in human breast milk; adverse effect on the nursing infant

    Adults

    Osteoarthritis

    1000-3000 mg PO q8-12hr

    Rheumatoid Arthritis

    1000-3000 mg PO q8-12hr

    Fever

    1000-1500 mg PO q12hr

    Renal Impairment

    Avoid use in severe renal impairment

    Other Indications & Uses

    Shoulder pain

    Pediatric

    Mild to Moderate Pain

    <37 kg: 50 mg/kg PO divided q12hr

    >37 kg: 2250 mg PO divided q12hr

    Fever

    <37 kg: 50 mg/kg PO divided q12hr

    >37 kg: 2250 mg PO divided q12hr

    Choline magnesium trisalicylate

    liquid

    • 500mg/5mL (294 mg choline salicylate, 362 mg magnesium salicylate)

    tablet

    • 500mg (294 mg choline salicylate, 362 mg magnesium salicylate)
    • 750mg (440 mg choline salicylate, 544 mg magnesium salicylate)
    • 1000mg (587 mg choline salicylate, 725 mg magnesium salicylate)