Skip to content

Chlorpropamide

    Brands

    DAE Class; Rx

    Common Brand Names; Diabinese

    • Antidiabetics, Sulfonylureas

    First-generation sulfonylurea; longest half-life of all the sulfonylureas
    Primarily used in adults for the treatment of type 2 diabetes mellitus; however, second-generation agents are preferred
    Uncommonly used as an alternative agent to DDAVP for treating central diabetes insipidus

    Indicated for the treatment of type 2 diabetes mellitus as an adjunct to diet and exercise

    For the treatment of central diabetes insipidus.

    Type I diabetes

    Diabetes ketoacidosis

    Hypersensitivity, sulfa allergy

    Severe renal impairment

    Dermatologic reactions

    Hypoglycemia

    Dizziness

    Headache

    Hepatic porphyria

    Liver failure

    Anorexia

    Agranulocytosis

    Aplastic anemia

    Nausea

    Disulfiram-like reactions

    Vomiting

    Blood dyscrasias

    Associated with greater number of side effects in the geriatric and renally impaired; should not be used as first line agent in these populations

    Cholestatic jaundice and hepatitis may occur rarely which may progress to liver failure

    Half life prolonged in renal failure

    Efficacy may decrease with prolonged use

    Patients with risk of severe hypoglycemia, especiall elderly, debilitated, or malnourished patients, patients with risk factors for cardiovascular events, severe liver impairment

    Pregnancy Category: C

    Lactation: Excretion in milk unknown/not recommended

    Adults

    750 mg/day PO.

    Elderly

    Avoid use.

    Adolescents

    Safety and efficacy have not been established.

    Children

    Safety and efficacy have not been established.

    Infants

    Safety and efficacy have not been established.

    Neonates

    Safety and efficacy have not been established.

    Chlorpropamide

    tablet

    • 100mg
    • 250mg

    Dosage should be individualized based upon patient’s response