General Description
Synonyms: 1,1-Difluoro-1-chloroethane; Dymel 142b; Genetron 142b; HCFC 142b; P-142b; propellant 142b; refrigerant 142b; Solkane 142b.
Description: Chlorodifluoroethane is a liquefied gas and exists as a liquid at room temperature when contained under its own vapor pressure, or as a gas when exposed to room temperature and atmospheric pressure. The liquid is practically odorless and colorless. Chlorodifluoroethane is noncorrosive and nonirritating.
Chemical Name: 1-Chloro-1,1-difluoroethane
Uses
Chlorodifluoroethane is a hydrochlorofluorocarbon (HCFC) aerosol propellant previously used in topical pharmaceutical formulations.
However, it is no longer permitted for use in pharmaceutical formulations because of its harmful effects on the environment.
It was also generally used in conjunction with difluoroethane to form a propellant blend with a specific gravity of 1.
Chlorodifluoroethane was also used in combination with chlorodifluoromethane and hydrocarbon propellants. Chlorodifluoroethane may be used as a vehicle for dispersions and emulsions.
Incompatibilities
Compatible with the usual ingredients used in the formulation of pharmaceutical aerosols. Chlorodifluoroethane can react vigorously with oxidizing materials.
Safety
Chlorodifluoroethane is no longer permitted for use as an aerosol propellant in topical pharmaceutical formulations. It is generally regarded as an essentially nontoxic and nonirritant material. Deliberate inhalation of excessive quantities of chlorofluorocarbon propellant may result in death, and the following ‘warning’ statements must appear on the label of all aerosols:
Handling Precautions
Chlorodifluoroethane is usually encountered as a liquefied gas and appropriate precautions for handling such materials should be taken. Eye protection, gloves, and protective clothing are recommended. Chlorodifluoroethane should be handled in a wellventilated environment. Chlorofluorocarbon vapors are heavier than air and do not support life; therefore, when cleaning large tanks that have contained chlorofluorocarbons, adequate provisions for oxygen supply in the tanks must be made in order to protect workers cleaning the tanks