Cellulose, Silicified Microcrystalline

Synonyms: ProSolv.

Description: Silicified microcrystalline cellulose is a synergistic, intimate physical mixture of two components: microcrystalline cellulose and colloidal silicon dioxide (for further information see Cellulose, Microcrystalline and Colloidal Silicon Dioxide). Silicified microcrystalline cellulose contains 2% w/w colloidal silicon dioxide.

Chemical Name: 

Tablet and capsule diluent

• Silicified microcrystalline cellulose is used as a filler in the formulation of capsules and tablets.

• It has improved compaction properties in both wet granulation and direct compression compared to conventional microcrystalline cellulose.

• Silicified microcrystalline cellulose was specifically developed to address the loss of compaction that occurs with microcrystalline cellulose after wet granulation.

• Silicified microcrystalline cellulose also appears to have beneficial properties for use in the formulation of powderfilled capsules

See Cellulose, Microcrystalline and Colloidal Silicon Dioxide.

See Cellulose, Microcrystalline and Colloidal Silicon Dioxide.

Observe normal precautions appropriate to the circumstances and quantity of material handled. Handling of silicified microcrystalline cellulose can generate nuisance dusts and the use of a respirator or dust mask may be necessary.

Cellulose, microcrystalline; colloidal silicon dioxide.