Cefpirome

Cefpirome

DAE Class; Rx

Common Brand Names; CEFROM

• Cephalosporins

Cefpirome is a fourth generation cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cefpirome is effective in a large variety of bacterial infections, such as respiratory tract, ear, skin, septicaemia, infections in immunocompromized patients and urinary tract infections. Antibiotics require constant drug level in body for therapeutic effect.This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefpirome is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

Cefpirome is primarily indicated in conditions like Bacteremia, Lower respiratory tract infections, Pneumonia, Promyelocytic leukemia, Septicaemia, Severe infections including bacteraemia and septicaemia and infections in neutropenic patients, Skin infections, Soft tissue infections, Urinary tract infection.

Cefpirome is contraindicated in conditions like Hypersensitivity.

The severe or irreversible adverse effects of Cefpirome, which give rise to further complications include Thrombocytopenia, Granulocytopenia, Agranulocytosis, Eosinophilia, Hemolytic anemia, Hemolytic anemia, Eelvated hepatic enzymes, Superinfection.

Cefpirome produces potentially life-threatening effects which include Anaphylaxis. which are responsible for the discontinuation of Cefpirome therapy.

The symptomatic adverse reactions produced by Cefpirome are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Abdominal pain, Rashes, Urticaria, Pseudomembranous colitis, Increase in liver enzymes.

Cefpirome should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs.

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.

Drug should not be given to Pregnant Mothers

Adult Dosage

1 to 2 g/12 hourly / IV

Paedriatic Dosage (20kg

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Neonatal Dosage (3kg)

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Cefpirome