Classes
DAE Class; Cefotaxime Rx
Common Brand Names; Claforan
- Cephalosporins, 3rd Generation
Description
Parenteral third-generation cephalosporin
Not effective for Pseudomonas aeruginosa infections
Used commonly for enteric gram-negative meningitis and sepsis, serious bacteremias, pneumonia, intra-abdominal infections, bone and joint infections, urinary tract infections, and skin and skin structure infections
Indications
Indicated for
Gonococcal Urethritis/Cervicitis
Gonorrhea, Rectal
Infections Caused by Susceptible Organisms
Preparation for Surgery
Contraindications
Documented hypersensitivity to drug or components
Adverse Effects
Colitis
Diarrhea
Elevated blood urea nitrogen (BUN) and creatinine
Elevated hepatic transaminases
Eosinophilia
Fever
Injection site pain
Nausea
Pruritus
Rash
Thrombocytopenia
Transient neutropenia
Vomiting
Warnings
Potentially life-threatening arrhythmia reported in patients receiving rapid bolus injection through central venous catheter
Prolonged treatment has been associated with granulocytopenia (>10 days)
Change infusion sites to minimize inflammation
Use with caution in patients with history of penicillin allergy
Use with caution in patients with history of colitis
Bacterial or fungal overgrowth of nonsusceptible organisms may occur with prolonged or repeated therapy
May need to adjust dose in renal impairment
Cefotaxime may potentiate the nephrotoxic effects of nephrotoxic drugs, including aminoglycosides, NSAIDs, and furosemide
Pregnancy and Lactation
Pregnancy category: B
Lactation: Drug enters breast milk; use with caution
Maximum Dosage
Adults
12 g/day IV/IM.
Geriatric
12 g/day IV/IM.
Adolescents
12 g/day IV/IM.
Children
Weighing 50 kg or more: 12 g/day IV/IM.
Weighing less than 50 kg: 180 mg/kg/day IV/IM is FDA-approved maximum; however, doses up to 300 mg/kg/day (Max: 12 g/day) have been used off-label for meningitis.
Infants
180 mg/kg/day IV/IM is FDA-approved maximum; however, doses up to 300 mg/kg/day have been used off-label for meningitis.
Neonates
8 days and older: 150 mg/kg/day IV/IM is FDA-approved maximum; however, doses up to 200 mg/kg/day have been used off-label for meningitis.
0 to 7 days: 100 mg/kg/day IV/IM is FDA-approved maximum; however, doses up to 150 mg/kg/day have been used off-label for meningitis.
How supplied
Cefotaxime
injectable solution
- 20mg/mL
- 40mg/mL
powder for injection
- 500mg
- 1g
- 2g
- 10g