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    DAE Class; Rx

    Common Brand Names; CEFOBID, Bicafar, Medocef

    • Cephalosporins

    Cefoperazone is a third generation semisynthetic,ß lactamase resistant cephalosporin antibiotic. Cephalosporins are derivatives of 7-aminocephalosporic acid and are closely related to penicillins in structure. Cephalosporins have a six membered sulfur containing ring adjoining a ß lactam ring. Cefoperazone is a broad spectrum antibiotic effective against a large range of aerobic and anaerobic gram positive and gram negative bacteria. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the medication at regular interval of time throughout the day and night as prescribed. Cefoperazone (Na) is important to take the drug for the full time period as prescribed. If you discontinue the therapy, it may result in ineffective treatment.

    • Upper Respiratory Tract Infection
      Cefoperazone is used in the treatment of upper respiratory tract infections such as sinusitis (swelling of the nasal passages and the surrounding cavities called sinuses), pharyngitis/tonsillitis (infections that cause swelling and soreness in your throat or tonsils), and pharyngotonsillitis (an infection that affects both the throat and tonsils).
    • Lower Respiratory Tract Infection
      Cefoperazone is used in the treatment of lower respiratory tract infections such as pneumonia (lung infection) and bronchitis (a condition that causes swelling of the bronchial tubes, the passages that carry the air to and from the lungs).
    • Urinary Tract Infection
      Urinary Tract Infection is an infection in any part of your urinary system. It may affect the kidneys, bladder, or urethra. The symptoms may include increased urge to urinate, pain during urination, blood in the urine, back pain, nausea, vomiting, fever, etc. Cefoperazone is used in the treatment of urinary tract infection.
    • Intraabdominal Infection
      Intra-abdominal infection is a broad term that includes a number of infections of the organs of the abdomen. It includes peritonitis (swelling of the lining of the stomach wall), diverticulitis (swelling of diverticula, one or more small pouches in the intestine), cholecystitis (swelling of the gallbladder), cholangitis (swelling of the bile duct that carries bile from the liver to the small intestine), and pancreatitis (swelling of the pancreas). Cefoperazone is used in the treatment of such conditions.
    • Bacterial Septicaemia
      Septicaemia is an infection of the blood caused by bacteria. The symptoms may include sweating, fast heartbeat, breathing difficulty, fatigue, weakness, difficulty breathing, fever and/or chills, etc. Cefoperazone is used in the treatment of bacterial septicaemia.
    • Skin and Soft tissue infections
      Skin and soft tissue infections are bacterial infections of the skin and its supporting structures. Cefoperazone is used in the treatment of skin and soft tissue infections.
    • Bone and Joint infections
      Cefoperazone is used in the treatment of bone and joint infections caused by bacteria.
    • Genital Infections
      Cefoperazone is used in the treatment of genital organ infections such as endometritis (swelling in the lining of the uterus), pelvic inflammatory disease (an infection of the female reproductive organs such as the uterus, fallopian tubes, or ovaries), etc
    Hypersensitivity to cefoperazone or other cephalosporins. History of severe hypersensitivity to β-lactams.

    Major & minor side effects for Cefoperazone

    • Diarrhoea
    • Nausea and Vomiting
    • Skin rash
    • Decrease in blood cell count
    • Decreased haemoglobin level
    • Headache
    • Pain at injection site
    • Fever with chills
    • Increased liver enzyme levels

    Cefoparazone should be used with caution in patients with impaired kidney or liver function. Appropriate measure should be taken if secondary infection occurs.

    Usage in pregnancy?
    Cefoperazone may be used during pregnancy upon your doctor’s recommendation as animal studies indicate no harm to the foetus. However, human data is not available. Hence, consult your doctor to understand the potential benefits and risks before receiving the medicine.
    Usage while breast-feeding?
    Cefoperazone may pass into the breastmilk in low amounts, hence it should be used with caution while breastfeeding. Consult your doctor if you are breastfeeding to understand the potential benefits and risks.

    Gynaecological infections, Intra-abdominal infections, Respiratory tract infections, Septicaemia, Skin and soft tissue infections, Urinary tract infection

    Adult: Usual dose: 1-2 g 12 hourly, may be increased up to 12 g daily in 2-4 divided doses in severe infections. Doses are given via IM inj or via intermittent (over 15 minutes to 1 hour) or continuous IV infusion.
    Child: Treatment recommendations may vary among countries and individual products (refer to specific product guidelines).



    • 250 mg
    • 500 mg
    • 1 g
    • 2 g