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Carbocisteine / Promethazine

    Brands

    Carbocisteine / Promethazine

    DAE Class; Rx

    Common Brand Names; RHINATHIOL PROMETH

    • Other Drugs Acting on the Respiratory System

    Carbocisteine is a mucolytic agent that reduces goblet cell hyperplasia in the management of respiratory disorders associated with abnormally excessive or viscous mucus secretion.
    Promethazine is a phenothiazine derivative which blocks postsynaptic mesolimbic dopaminergic receptors in the brain. It exhibits a strong α-adrenergic blocking effect and depresses the release of hypothalamic and hypophyseal hormones. It competes with histamine for the H1-receptor; muscarinic blocking effect may be responsible for antiemetic activity. It also reduces stimuli to the brainstem reticular system.
    Onset: Promethazine: Approx 20 minutes.

    Indicated in Respiratory tract infections associated with excessive and/or viscous mucus

    Active peptic ulcer. Children <2 years.

    Significant: Anticholinergic effects (e.g. blurred vision, dry mouth, urinary retention). Drowsiness, dizziness, restlessness, headache, nightmare, tiredness, disorientation, photosensitivity.
    Gastrointestinal disorders: Nausea, gastric discomfort, GI bleeding, diarrhoea.
    Skin and subcutaneous tissue disorders: Rarely, rash, urticaria, pruritus.
    Potentially Fatal: Respiratory depression and apnoea especially in children.

    Patient with epilepsy, signs and symptoms suggestive of Reye’s syndrome. Children >2 years. Pregnancy and lactation.

    Oral
    Respiratory tract infections associated with excessive and/or viscous mucus

    Adult: Available preparation:
    Each bottle contains carbocisteine 100 mg and promethazine hydrochloride 2.5 mg
    15 mL tid.
    Child: Each bottle contains carbocisteine 100 mg and promethazine hydrochloride 2.5 mg
    <2 years Not recommended. 2-5 years 2.5-5 mL four times a day. 6-12 years 7.5-12.5 mL tid. 12-15 years 12.5-15 mL tid.

    Carbocisteine / Promethazine

    Syrup