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Calcium Phosphate, Dibasic Dihydrate

    Synonyms:  Calcii lactas pentahydricus; calcium bis(2-hydroxypropanoate) pentahydrate; calcium dilactate; calcium lactate (1:2) hydrate; calcium lactate (1:2) pentahydrate; E327; 2-hydroxypropanoic acid, calcium salt; lactic acid, calcium salt; mixture of calcium (2R)-, (2S)- and (2RS)-2-hydroxypropanoates pentahydrates; propanoic acid, 2-hydroxy-, calcium salt (2:1), hydrate; Puracal

    Description: Calcium chloride occurs as a white or colorless crystalline powder, granules, or crystalline mass, and is hygroscopic (deliquescent).

    Chemical Name: Calcium lactate anhydrous

    Calcium lactate monohydrate and trihydrate

    Calcium lactate pentahydrate

    • Dibasic calcium phosphate dihydrate is widely used in tablet formulations both as an excipient and as a source of calcium and phosphorus in nutritional supplements.

    • It is one of the more widely used materials, particularly in the nutritional/health food sectors.

    • It is also used in pharmaceutical products because of its compaction properties, and the good flow properties of the coarsegrade material.

    • The predominant deformation mechanism of dibasic calcium phosphate coarse-grade is brittle fracture and this reduces the strain-rate sensitivity of the material, thus allowing easier transition from the laboratory to production scale.

    • However, dibasic calcium phosphate dihydrate is abrasive and a lubricant is required for tableting, for example about 1% w/w of magnesium stearate or about 1% w/w of sodium stearyl fumarate is commonly used.

    Dibasic calcium phosphate dihydrate should not be used to formulate tetracycline antibiotics. Dibasic calcium phosphate dihydrate has been reported to be incompatible with indomethacin, aspirin, aspartame, ampicillin, cephalexin, and erythromycin. The surface of dibasic calcium phosphate dihydrate is alkaline and consequently it should not be used with drugs that are sensitive to alkaline pH

    Dibasic calcium phosphate dihydrate is widely used in oral pharmaceutical products, food products, and toothpastes, and is generally regarded as a nontoxic and nonirritant material. However, oral ingestion of large quantities may cause abdominal discomfort.

    Observe normal precautions appropriate to the circumstances and quantity of material handled. The fine-milled grades can generate nuisance dusts and the use of a respirator or dust mask may be necessary.

    Calcium phosphate, dibasic anhydrous; calcium phosphate, tribasic.