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Calcium Lactate

    Synonyms:  Calcii lactas pentahydricus; calcium bis(2-hydroxypropanoate) pentahydrate; calcium dilactate; calcium lactate (1:2) hydrate; calcium lactate (1:2) pentahydrate; E327; 2-hydroxypropanoic acid, calcium salt; lactic acid, calcium salt; mixture of calcium (2R)-, (2S)- and (2RS)-2-hydroxypropanoates pentahydrates; propanoic acid, 2-hydroxy-, calcium salt (2:1), hydrate; Puracal

    Description: Calcium chloride occurs as a white or colorless crystalline powder, granules, or crystalline mass, and is hygroscopic (deliquescent).

    Chemical Name: Calcium lactate anhydrous

    Calcium lactate monohydrate and trihydrate

    Calcium lactate pentahydrate

    Antimicrobial preservative; buffering agent; crosslinking agent; tablet and capsule diluent; tablet binder; tablet filler; therapeutic agent; thickening agent.

    • Calcium lactate is used as a bioavailability enhancer and nutrient supplement in pharmaceutical formulations.

    • A spray-dried grade of calcium lactate pentahydrate has been used as a tablet diluent in direct compression systems, and has been shown to have good compactability.

    • The properties of the pentahydrate form have been considered superior to those of calcium lactate trihydrate when used in direct compression tablet formulations.

    • Tablet properties may be affected by the hydration state of the calcium lactate and particle size of the material: reducing particle size increased crushing strength, whereas storage of tablets at elevated temperature resulted in dehydration accompanied by a reduction in crushing strength.

    • Calcium lactate has also been used as the source of calcium ions in the preparation of calcium alginate microspheres for controlledC 92 Calcium Lactate release delivery of active agents.

    • It has been shown to result in lower calcium concentrations in the finished microspheres when compared with calcium acetate.

    • Therapeutically, calcium lactate has been used in preparations for the treatment of calcium deficiency.

    Calcium salts, including the lactate, can display physical incompatibility with phosphate in the diet or therapeutic preparations, for example in enteral feed mixtures.

    Calcium lactate was found to have no toxic or carcinogenic effects when dosed at levels of 0%, 2.5%, and 5% in drinking water to male and female rats for 2 years

    Observe normal precautions appropriate to the circumstances and
    quantity of the material handled.

    Lactic acid; sodium lactate.