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Brompheniramine/Dextromethorphan/Phenylephrine

    Brands

    DEA Class; OTC

    Common Brand Names; Neo DM Suspension, Dimaphen DM, Children’s Dimetapp Cold & Cough

    • Cough/Cold, Non-narcotic Combos; 
    • Antihistamine/Antitussive/Decongestant Combos

    Oral sedating antihistamine and non-opioid antitussive combination
    Used to relieve symptoms associated with the common cold or allergies including rhinorrhea, sneezing, and cough in adults and pediatric patients 6 years and older
    These products may be abused due to dextromethorphan content and are known by the slang term “Triple C”

    Indicated for the Relief of Cold Symptoms

    • Hypersensitivity
    • Newborn infants, premature infants
    • Nursing mothers
    • Severe hypertension
    • Severe coronary artery disease or ischemic heart disease
    • Use within 14 days of MAO inhibitor
    • Narrow-angle glaucoma
    • Urinary retention
    • Peptic ulcer
    • During asthma attack
    • Treatment of lower respiratory tract conditions, including asthma
    • Dizziness
    • Drowsiness
    • Dry mouth, throat, and nose
    • Thickening of mucus in nose or throat GI disturbances
    • Reflex tachycardia
    • Excitability
    • Restlessness
    • Headache
    • Hypertension
    • Severe peripheral and visceral vasoconstriction

    Do not use the medicine to make a child sleepy; misuse of this medicine may cause death in very young children

    See healthcare professional if symptoms do not improve after 7 days, or experiencing fever, rash, or headaches

    If surgery or medical tests need to be performed, tell doctor ahead of time if medicine taken within past few days

    Avoid becoming overheated or dehydrated during exercise and hot weather; this medicine can decrease sweating and you may be more prone to heat stroke

    Patients with persistent cough, such as occurs with smoking, asthma, emphysema, or where cough is accompanied by excessive secretions should not take this product; persistent cough may be sign of serious condition

    If cough persists for more than 1 week, tends to recur, or is accompanied by fever, rash, or persistent headache, consult a doctor

    Use caution when giving to children or patients with chronic pulmonary disease, shortness of breath, difficulty in breathing, asthma, emphysema, high blood pressure, heart disease, diabetes, thyroid disease, or difficulty in urination due to enlargement of the prostate gland unless directed by a physician

    Antihistamines may impair mental and physical abilities required for performance of potentially hazardous tasks, such as driving a car or operating machinery and may impair mental alertness in children

    At doses higher than recommended dose, nervousness, dizziness, or sleeplessness may occur; especially in infants and small children, antihistamines in overdosage may cause hallucinations, convulsions, and death

    If nervousness, dizziness, or sleeplessness occurs, discontinue use and consult healthcare professional

    Administration of dextromethorphan hydrobromide may be accompanied by histamine release and should be used with caution in atopic children

    If hypertensive crisis occurs, these drugs should be discontinued immediately and therapy to lower blood pressure instituted immediately; fever should be managed by means of external cooling

    Animal reproduction studies not conducted; also not known whether drug combination can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity; medication should be given to a pregnant woman only if clearly needed

    Because of higher risk of intolerance of antihistamines in small infants generally, and in newborns and prematures in particular, this medication is contraindicated in nursing mothers

    Do not exceed recommended dosage limits for the specific product prescribed; the following are general guidelines:

    Adults

    Chlorpheniramine 24 mg/day PO; dextromethorphan 120 mg/day PO.

    Geriatric

    Chlorpheniramine 24 mg/day PO; dextromethorphan 120 mg/day PO.

    Adolescents

    Chlorpheniramine 24 mg/day PO; dextromethorphan 120 mg/day PO.

    Children

    12 years: Chlorpheniramine 24 mg/day PO; dextromethorphan 120 mg/day PO.
    6 to 11 years: Chlorpheniramine 12 mg/day PO; dextromethorphan 60 mg/day PO.
    Less than 6 years: Safety and efficacy have not been established.

    Infants

    Safety and efficacy have not been established.

    Brompheniramine maleate/dextromethorphan hydrobromide/phenylephrine hydrochloride 

    Brompheniramine/dextromethorphan/phenylephrine

    oral solution

    • (1mg/5mg/2.5mg)/5mL