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Benzoyl Peroxide/​Tretinoin

    Brands

    DEA Class; Rx

    Common Brand Names; Twyneo

    • Acne Agents, Topical Combos

    Naturally occurring retinoid analog; also known as all-trans-retinoic acid (aTRA)
    Oral form used in acute promyelocytic leukemia; topical form used for cutaneous disorders like acne and photoaging
    Treatment with oral form may cause acute promyelocytic leukemia differentiation syndrome

    Indicated for topical treatment of acne vulgaris

    Hypersensitivity to benzoyl peroxide or any components of the product

    • Erythema, mild (33%)
    • Pigmentation, mild (27.3%)
    • Dryness, mild (22.3%)
    • Scaling, mild (16.4%)
    • Itching, mild (11.1%)
    • Application site pain (10.6%)
    • Erythema, moderate (6.9%)
    • Pigmentation, moderate (6.3%)
    • Burning, mild (5.9%)
    • Stinging, mild (5.3%)
    • Dryness, moderate (5.3%)
    • Application site dryness (4.9%)
    • Application site exfoliation (4.1%)
    • Application site erythema (4%)
    • Scaling, moderate (2.6%)
    • Burning, moderate (2.2%)
    • Itching, moderate (1.8%)
    • Application site dermatitis (1.3%)
    • Application site pruritus (1.3%)
    • Application site irritation (1.1%)

    Severe hypersensitivity reactions (eg, anaphylaxis, angioedema) reported with use of benzoyl peroxide products; if a serious hypersensitivity reaction occurs, discontinue therapy immediately and initiate appropriate therapy

    Pain, dryness, exfoliation, erythema, and irritation may occur

    Avoid application to cuts, abrasions, eczematous, or sunburned skin

    Minimize unprotected exposure to sunlight and sunlamps; use sunscreen and protective clothing when sun exposure cannot be avoided; discontinue therapy at first evidence of sunburn

    No data are available on use in pregnant females

    Topical tretinoin: Available data from published observational studies in pregnant females have not established a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes

    Topical benzyl peroxide: Studies conducted with topical benzoyl peroxide have not demonstrated systemic absorption and maternal use is not expected to result in fetal exposure to benzoyl peroxide

    No data available on presence of benzoyl peroxide and tretinoin or its metabolites in human milk, effects on breastfed infants, or effects on milk production

    Apply a thin layer to affected areas qDay

    Tretinoin/benzoyl peroxide

    topical cream

    • 0.1%/3%